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Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

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Abstract

In addition to its previously characterized, six different polypeptide components, signal recognition protein—which functions in protein translocation across and integration into the endoplasmic reticulum membrane—contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein—which we therefore rename signal recognition particle.

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Authors and Affiliations

  1. The Rockefeller University, New York, New York, 10021, USA

    Peter Walter & Günter Blobel

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  1. Peter Walter
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  2. Günter Blobel
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Walter, P., Blobel, G. Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature 299, 691–698 (1982). https://doi.org/10.1038/299691a0

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