Abstract
On emergence of the signal sequence of nascent secretory proteins from the large ribosomal subunit, translation is stopped by a cytoplasmic protein complex. A specific membrane protein of the endoplasmic reticulum, the ‘docking protein’, releases this block and allows further synthesis to be directly coupled to transfer across the membrane.
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Meyer, D., Krause, E. & Dobberstein, B. Secretory protein translocation across membranes—the role of the ‘docking protein’. Nature 297, 647–650 (1982). https://doi.org/10.1038/297647a0
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DOI: https://doi.org/10.1038/297647a0
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