Skip to main content
SpringerLink
Log in

Actin-binding proteins—regulators of cell architecture and motility

  • Review Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Numerous actin-binding proteins from a variety of cell types have been described. Here I attempt to correlate the properties and functions of some of these. Three major classes have been identified: (1) cross-linking proteins which form filament bundles or isotropic gels; (2) proteins which cap filament ends and nucleate the polymerization of G-actin (many of these also sever actin filaments); (3) proteins which bind to G-actin and stabilize the monomer pool. Some of the proteins described here combine the properties of more than one class and the activities of many of them are regulated by changes in Ca2+ ion concentration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Buckley, I. K. & Porter, K. R. Protoplasma 64, 345–349 (1967).

    Article  Google Scholar 

  2. Lazarides, E. & Weber, K. Proc. natn. Acad. Sci. U.S.A. 71, 2268–2272 (1974).

    Article  ADS  CAS  Google Scholar 

  3. Webster, R. E., Osborn, M. & Weber, K. Expl Cell Res. 117, 47–61 (1974).

    Article  Google Scholar 

  4. Lazarides, E. J. supramolec. Struct. 5, 531–563 (1976).

    Article  CAS  Google Scholar 

  5. Lazarides, E. & Burridge, K. Cell 6, 289–298 (1975).

    Article  CAS  PubMed  Google Scholar 

  6. Wolosewick, J. & Porter, K. R. J. Cell Biol. 82, 114–139 (1979).

    Article  CAS  PubMed  Google Scholar 

  7. Heuser, J. & Kirschner, M. W. J. Cell Biol. 86, 212–234 (1979).

    Article  Google Scholar 

  8. Hitchcock, S. E. J. Cell Biol. 74, 1–15 (1977).

    Article  CAS  PubMed  Google Scholar 

  9. Korn, E. D. Proc. natn. Acad. Sci. U.S.A. 75, 588–599 (1978).

    Article  ADS  CAS  Google Scholar 

  10. Taylor, D. L. & Condeelis, J. S. Int. Rev. Cytol. 56, 57–144 (1979).

    Article  CAS  PubMed  Google Scholar 

  11. Uyemura, D. G. & Spudich, J. A. in Biological Regulation and Development Vol. 2 (ed. Goldberger, R. F.) 317–338 (Plenum, New York, 1980).

    Book  Google Scholar 

  12. Vandekerckhove, J. & Weber, K. J. molec. Biol. (1978) 126, 783–802 (1978).

    Article  CAS  PubMed  Google Scholar 

  13. Oosawa, F. & Asakura, S. Thermodynamics of the Polymerization of Proteins (Academic, London, 1975).

  14. Wegner, A. J. molec. Biol. 108, 139–150 (1976).

    Article  CAS  PubMed  Google Scholar 

  15. Pollard, T. D. & Mooseker, M. S. J. Cell Biol. 88, 654–659 (1981).

    Article  CAS  PubMed  Google Scholar 

  16. Margolis, R. L. & Wilson, L. Cell 13, 1–8 (1978).

    Article  CAS  PubMed  Google Scholar 

  17. Pardee, J. D., Simpson, P. A., Stryer, L. & Spudich, J. A. J. Cell Biol. (in the press).

  18. Kirschner, M. W. J. Cell Biol. 86, 330–334 (1980).

    Article  CAS  PubMed  Google Scholar 

  19. Carlsson, L., Nystrom, L.-E., Sundkvist, L., Markey, F. & Lindberg, U. J. molec. Biol. 115, 465–483 (1977).

    Article  CAS  PubMed  Google Scholar 

  20. Harris, H. E. & Weeds, A. G. FEBS Lett. 90, 84–88 (1978).

    Article  CAS  PubMed  Google Scholar 

  21. Reichstein, E. & Korn, E. D. J. biol. Chem. 254, 6174–6179 (1979).

    Article  CAS  PubMed  Google Scholar 

  22. Lazarides, E. & Linberg, U. Proc. natn. Acad. Sci. U.S.A. 71, 4742–4746 (1974).

    Article  ADS  CAS  Google Scholar 

  23. Brenner, S. L. & Korn, E. D. J. biol. Chem. 254, 9982–9985 (1979).

    Article  CAS  PubMed  Google Scholar 

  24. Flanagan, M. D. & Lin, S. J. biol. Chem. 255, 835–838 (1980).

    Article  CAS  PubMed  Google Scholar 

  25. McLean-Fletcher, S. & Pollard, T. D. Cell 20, 329–341 (1980).

    Article  Google Scholar 

  26. Brown, S. S. & Spudich, J. A. J. Cell Biol. 88, 487–491 (1981).

    Article  CAS  PubMed  Google Scholar 

  27. Wang, K., Ash, J. F. & Singer, S. J. Proc. natn. Acad. Sci. U.S.A. 72, 4483–4486 (1975).

    Article  ADS  CAS  Google Scholar 

  28. Hartwig, J. H. & Stossel, T. D. J. biol. Chem. 250, 5699–5705 (1975).

    Article  Google Scholar 

  29. Tyler, J. M., Anderson, J. M. & Branton, D. J. Cell Biol. 85, 489–495 (1980).

    Article  CAS  PubMed  Google Scholar 

  30. Brotschi, E. A., Hartwig, J. H. & Stossel, T. P. J. biol. Chem. 253 8988–8993 (1978).

    Article  CAS  PubMed  Google Scholar 

  31. Hartwig, J. H. & Stossel, T. P. J. molec. Biol. 145, 563–581 (1981).

    Article  CAS  PubMed  Google Scholar 

  32. Stendahl, O. I. & Stossel, T. P. Biochem. biophys. Res. Commun. 92, 675–681 (1980).

    Article  CAS  PubMed  Google Scholar 

  33. Hartwig, J. H., Tyler, J. & Stossel, T. P. J. Cell Biol. 87, 841–848 (1981).

    Article  Google Scholar 

  34. Valerius, N. H., Stendahl, O. I., Hartwig, J. H. & Stossel, T. P. Cell 24, 195–202 (1981).

    Article  CAS  PubMed  Google Scholar 

  35. Nunnally, M. H., D'Angelo, J. M. & Craig, S. W. J. Cell Biol. 87, 219–226 (1980).

    Article  CAS  PubMed  Google Scholar 

  36. Steck, T. L. J. Cell Biol. 62, 1–19 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Branton, D., Cohen, C. M. & Tyler, J. Cell 24, 24–32 (1981).

    Article  CAS  PubMed  Google Scholar 

  38. Gratzer, W. S. Biochem. J. 198, 1–8 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Condeelis, J., Salisbury, J. & Fujiwara, K. Nature 292, 161–163 (1981).

    Article  ADS  CAS  Google Scholar 

  40. Condeelis, J. & Geosits, S. J. Cell Biol. (in the press).

  41. Ebashi, S., Ebashi, F. & Maruyama, K. Nature 203, 645–6 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Granger, B. L. & Lazarides, E. Cell 15, 1253–1268 (1978).

    Article  CAS  PubMed  Google Scholar 

  43. Suzuki, A. et al. J. Biol. Chem. 251, 6860–6870 (1976).

    Article  CAS  PubMed  Google Scholar 

  44. Zeece, M. G., Robson, R. M. & Betchtel, P. J. Biochim. biophys. Acta 581, 365–370 (1979).

    Article  CAS  PubMed  Google Scholar 

  45. Geiger, B. Cell 18, 193–205 (1979).

    Article  CAS  PubMed  Google Scholar 

  46. Geiger, B., Tokuyasu, K. T. & Singer, S. J. Proc. natn. Acad. (1979).

  47. Burridge, K. & McCullough, L. J. J. supramolec. Struct. 13, 53–65 (1980).

    Article  CAS  Google Scholar 

  48. Jockusch, B. M. & Isenberg, G. Proc. natn. Acad. Sci. U.S.A. 78, 3005–3009 (1981).

    Article  ADS  CAS  Google Scholar 

  49. Burridge, K. & Feramisco, J. R. Nature 294, 565–567 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  50. Burridge, K. & Feramisco, J. R. Cold Spring Harb. Symp. quant Biol. 46 (in the press).

  51. Mimura, M. & Asano, A. Nature 282, 44–48 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  52. Hellewell, S. B. & Taylor, D. L. J. Cell Biol. 83, 633–648 (1979).

    Article  CAS  PubMed  Google Scholar 

  53. Condeelis, J. Int. Cell Biol. (ed. Schweiger, H.) 306–320 (Springer, Berlin, 1981).

  54. Pollard, T. D. J. biol. Chem. 256, 7666–7670 (1981).

    Article  CAS  PubMed  Google Scholar 

  55. Blikstad, L., Eriksson, S. & Carlsson, L. Eur. J. Biochem. 109, 317–323 (1980).

    Article  CAS  PubMed  Google Scholar 

  56. Burridge, K. & Feramisco, J. R. Cell 19, 587–595 (1980).

    Article  CAS  PubMed  Google Scholar 

  57. Avnur, Z. & Geiger, B. J. molec. Biol. 153, 361–379 (1981).

    Article  CAS  PubMed  Google Scholar 

  58. Jockusch, B. M. & Isenberg, G. Cold Spring Harb. Symp. quant. Biol. 46 (in the press).

  59. Kane, R. E. J. Cell Biol. 66, 305–315 (1975).

    Article  CAS  PubMed  Google Scholar 

  60. Bryan, J. & Kane, R. E. J. molec. Biol. 207–224 (1978).

  61. Otto, J. J., Kane, R. E. & Bryan, J. Cell Motility 1, 31–40 (1980).

    Article  CAS  PubMed  Google Scholar 

  62. Bretscher, A. & Weber, K. J. Cell Biol. 86, 335–340 (1980).

    Article  CAS  PubMed  Google Scholar 

  63. Glenney, J. R., Kaulfus, P., Matsudaira, P. & Weber, K. J. biol. Chem. 256, 9283–9288 (1981).

    Article  CAS  PubMed  Google Scholar 

  64. Maruyama, K. et al. J. Biochem. 81, 215–232 (1977).

    Article  CAS  PubMed  Google Scholar 

  65. Yin, H. L. & Stossel, T. P. Nature 281, 583–586 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  66. Yin, H. L. & Stossel, T. P. J. biol. Chem. 255, 9494–9493 (1980).

    Article  CAS  PubMed  Google Scholar 

  67. Yin, H. L., Zaner, K. S. & Stossel, T. P. J. biol. Chem. 255, 9494–9500 (1980).

    Article  CAS  PubMed  Google Scholar 

  68. Flory, P. J. Principles of Polymer Chemistry (Cornell University Press, New York, 1953).

  69. Wang, L.-L. & Bryan, J. Cell 25, 637–649 (1981).

    Article  CAS  PubMed  Google Scholar 

  70. Yin, H. L., Maruyama, K. & Stossel, T. P. J. biol Chem. 256, 9693–9697 (1981).

    Article  CAS  PubMed  Google Scholar 

  71. Chaponnier, C., Borgia, R., Rungger-Brandle, E., Weil, R. & Gabbiani, C. Experientia 35, 1039–1041 (1979).

    Article  CAS  PubMed  Google Scholar 

  72. Norberg, R., Thorstensson, R., Utter, G. & Fragraeus, A. Aur. J. Biochem. 100, 575–583 (1979).

    CAS  Google Scholar 

  73. Harris, H. E., Bamburg, J. R. & Weeds, A. G. FEBS Lett. 121, 175–177 (1980).

    Article  CAS  PubMed  Google Scholar 

  74. Harris, H. E. & Gooch, J. FEBS Lett. 123, 49–53 (1981).

    Article  CAS  PubMed  Google Scholar 

  75. Harris, D. A. & Schwartz, J. H. Proc. natn. Acad. ScL U.S.A. 78, 6798–6802 (1981).

    Article  ADS  CAS  Google Scholar 

  76. Yin, H. L., Albrecht, J. H. & Fattoum, A. J. Cell Biol. 91, 901–906 (1981).

    Article  CAS  PubMed  Google Scholar 

  77. Harris, H. E., Bamburg, J. R., Bernstein, B. W. & Weeds, A. G. Analyt. Biochem. 119, 102–114 (1982).

    Article  CAS  PubMed  Google Scholar 

  78. Hasegawa, T., Takahashi, S., Hayashi, H. & Hatano, S. Biochemistry 19, 2677–2683 (1980).

    Article  CAS  PubMed  Google Scholar 

  79. Hinssen, H. Eur. J. Cell Biol. 23, 225–233 (1981).

    CAS  PubMed  Google Scholar 

  80. Hinssen, H. Eur. J. Cell Biol. 23, 234–240 (1981).

    CAS  PubMed  Google Scholar 

  81. Brown, S. S., Yamamoto, K. & Spudich, J. A. J. Cell Biol. (in the press).

  82. Isenberg, G., Aebi, U. & Pollard, T. D. Nature 288, 455–459 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  83. Bamburg, J. R., Harris, H. E. & Weeds, A. G. FEBS Lett. 121, 178–182 (1980).

    Article  CAS  PubMed  Google Scholar 

  84. Mooseker, M. S. & Tilney, L. G. J. Cell Biol. 67, 725–743 (1975).

    Article  CAS  PubMed  Google Scholar 

  85. Matsudaira, P. T. & Burgess, D. R. J. Cell Biol. 83, 667–673 (1979).

    Article  CAS  PubMed  Google Scholar 

  86. Howe, C. L., Mooseker, M. S. & Graves, T. A. J. Cell Biol. 86 916–923 (1980).

    Article  Google Scholar 

  87. Glenney, J. R., Bretscher, A. & Weber, K. Proc. natn. Acad. Sci. U.S.A. 77, 6458–6462 (1980).

    Article  ADS  CAS  Google Scholar 

  88. Bretscher, A. & Weber, K. Proc. natn. Acad. Sci. U.S.A. 76, 2321–2325 (1979).

    Article  ADS  CAS  Google Scholar 

  89. Bretscher, A. & Weber, K. Cell 20, 839–847 (1980).

    Article  CAS  PubMed  Google Scholar 

  90. Glenney, J. R., Kaulfus, P. & Weber, K. Cell 24, 471–480 (1981).

    Article  CAS  PubMed  Google Scholar 

  91. Craig, S. W. & Powell, L. D. Cell 22, 739–746 (1980).

    Article  CAS  PubMed  Google Scholar 

  92. Mooseker, M. S., Graves, T. A., Wharton, K. A., Falco, N. & Howe, C. L. J. Cell Biol. 87, 809–822 (1980).

    Article  CAS  PubMed  Google Scholar 

  93. Matsudaira, P. T. & Burgess, D. R. J. Cell Biol. (in the press).

  94. Glenney, J. R. & Weber, K. Proc. natn. Acad. Sci. U.S.A. 78, 2810–2814 (1981).

    Article  ADS  CAS  Google Scholar 

  95. Glenney, J. R., Geisler, N., Kaulfus, P. & Weber, K. J. biol. Chem. 256, 8156–8161 (1981).

    Article  CAS  PubMed  Google Scholar 

  96. Drenckhahn, D. & Groschel-Stewart, U. J. Cell Biol. 86, 475–482 (1980).

    Article  CAS  PubMed  Google Scholar 

  97. Herman, I-M. & Pollard, T. D. J. Cell Biol. 88, 346–351 (1981).

    Article  CAS  PubMed  Google Scholar 

  98. Kendrick-Jones, J. & Scholey, J. J. Muscle Res. Cell Motility 2, 347–372 (1981).

    Article  CAS  Google Scholar 

  99. Stossel, T. P., Hartwig, J. H., Yin, H. L., Zaner, K. S. & Stendahl, O. Cold Spring Harb. Symp. quant. Biol. 46 (in the press).

  100. Tilney, L. G., Binder, E. M. & DeRosier, D. J. J. Cell Biol. 90, 485–494 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Tilney, L. G., Hatano, S., Ishikawa, H. & Mooseker, M. S. J. Cell Biol. 59, 109–126 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Tilney, L. G., Kiehart, D. P., Sardet, C. & Tilney, M. J. Cell Biol. 77, 536–550 (1978).

    Article  CAS  PubMed  Google Scholar 

  103. Carlsson, L., Markey, F., Blikstad, I., Persson, T. & Lindberg, U. Proc. natn. Acad. Sci. U.S.A. 76, 6376–6380 (1979).

    Article  ADS  CAS  Google Scholar 

  104. Casella, J. F., Flanagan, M. D. & Lin, S. Nature 293, 302–305 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  105. Taylor, D. L. & Wang, Y-L. Nature 284, 405–410 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Alan Weeds

Authors
  1. Alan Weeds
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weeds, A. Actin-binding proteins—regulators of cell architecture and motility. Nature 296, 811–816 (1982). https://doi.org/10.1038/296811a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/296811a0

  • Springer Nature Limited

This article is cited by

Search

Navigation