Abstract
The lethality of tumours is determined largely by their ability to metastasize to distant sites. Once metastasis has occurred, eradication of the tumour cells from the body becomes difficult or impossible. Although the steps involved in tumour metastasis have been well documented (for review see refs 1–3), the cellular parameters that influence the tendency of tumours to metastasize have been more difficult to define4–7, and the underlying genetic determinants of metastatic potential are not known. We are studying the metastasis of tumours induced in hamsters by simian virus 40 (SV40). We show here that tumours induced by a viral mutant (d1884) in the small T antigen gene tend to metastasize, whereas tumours induced by wild-type SV40 rarely do so. Thus, we have a well defined system in which the underlying genetic differences in the transforming viruses are known and in which we may be able to correlate these differences with cellular parameters that determine tumour metastasis.
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Dixon, K., Ryder, BJ. & Burch-Jaffe, E. Enhanced metastasis of tumours induced by a SV40 small T deletion mutant. Nature 296, 672–675 (1982). https://doi.org/10.1038/296672a0
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DOI: https://doi.org/10.1038/296672a0
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