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Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing

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Abstract

A dispersed immunoglobulin pseudogene carries two hallmarks of RNA processing—spliced J and C regions and a poly (A)-rich tail. Its discovery strengthens the notion that processed genes are a significant feature of the mammalian genome and that genetic information can return to the genome via an RNA intermediate.

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Authors and Affiliations

  1. Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Gregory F. Hollis, Philip A. Hieter & Philip Leder

  2. Laboratory of Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    O. Wesley McBride

  3. Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    David Swan

  4. Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Philip Leder

Authors
  1. Gregory F. Hollis
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  2. Philip A. Hieter
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  3. O. Wesley McBride
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  4. David Swan
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  5. Philip Leder
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Hollis, G., Hieter, P., McBride, O. et al. Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing. Nature 296, 321–325 (1982). https://doi.org/10.1038/296321a0

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  • DOI: https://doi.org/10.1038/296321a0

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