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Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA

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Abstract

The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.

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Authors and Affiliations

  1. University of Oregon, Eugene, Oregon, 97403, USA

    Michael Comb & Edward Herbert

  2. Genentech Corporation, 460 Point San Bruno Boulevard, San Francisco, California, 94080, USA

    Peter H. Seeburg & John Adelman

  3. National Institutes of Health, Bethesda, Maryland, 20205, USA

    Lee Eiden

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  1. Michael Comb
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  2. Peter H. Seeburg
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  3. John Adelman
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  4. Lee Eiden
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  5. Edward Herbert
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Comb, M., Seeburg, P., Adelman, J. et al. Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA. Nature 295, 663–666 (1982). https://doi.org/10.1038/295663a0

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