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Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids

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Abstract

Fusions between the mouse mammary tumour virus long terminal repeat and a mouse dihydrofolate reductase cDNA have been constructed in a SV40 vector. When these plasmids are transferred into recipient cells, the production of dihydrofolate reductase is regulated by glucocorticoid hormones. These results define a hormonally responsive region of the viral genome.

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Author notes

  1. Richard Mulligan

    Present address: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

Authors and Affiliations

  1. Department of Pharmacology, Stanford University School of Medicine, Stanford, California, 94305, USA

    Frank Lee & Gordon Ringold

  2. Department of Biochemistry, Stanford University School of Medicine, Stanford, California, 94305, USA

    Richard Mulligan & Paul Berg

Authors
  1. Frank Lee
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  2. Richard Mulligan
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  3. Paul Berg
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  4. Gordon Ringold
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Lee, F., Mulligan, R., Berg, P. et al. Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids. Nature 294, 228–232 (1981). https://doi.org/10.1038/294228a0

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  • DOI: https://doi.org/10.1038/294228a0

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