Abstract
The major late adenovirus promoter is active early after infection, selectively producing messenger RNAs coding for polypeptides with molecular weights of 55,000, 52,000 and 14,000. This selective expression suggests that a differential splicing pattern occurs at the transition from early to late viral gene expression. Activation of the late promoter and splicing of the 55, 52K mRNAs does not require newly synthesized virus polypeptides.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ziff, E. B. & Evans, R. M. Cell 15, 1463–1475 (1978).
Evans, R. M. et al. Cell 12, 733–739 (1977).
Nevins, J. R. & Darnell, J. E. J. Virol. 25, 811–823 (1978).
Ziff, E. B. & Fraser, N. J. Virol. 25, 897–906 (1978).
McGrogan, M. & Raskas, H-J. Proc. natn. Acad. Sci. U.S.A. 75, 625–629 (1978).
Berget, S. M., Moore, C. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 74, 3171–3175 (1977).
Chow, L. T., Gelinas, R., Broker, T. & Roberts, R. J. Cell 12, 1–8 (1977).
Mathews, M. B. & Pettersson, U. J. molec. Biol. 119, 293–328 (1978).
Akusjärvi, G., Mathews, M. B., Andersson, P., Vennström, B. & Pettersson, U. Proc. natn. Acad. Sci. U.S.A. 77, 2424–2428 (1980).
Chow, L. T. & Broker, T. Cell 15, 497–510 (1978).
Fraser, N. W., Sehgal, P. B. & Darnell, J. E. Proc. natn. Acad. Sci. U.S.A. 76, 2571–2575 (1979).
Chow, L. T., Broker, T. R. & Lewis, J. B. J. molec. Biol. 134, 265–303 (1979).
Kitchingman, G. R. & Westphal, H. J. molec. Biol. 137, 23–48 (1980).
Weil, P. A., Luse, D. S., Segall, J. & Roeder, R. G. Cell 18, 469–484 (1979).
Wasylyk, B., Kedinger, C., Corden, J., Brison, O. & Chambon, P. Nature 285, 367–372 (1980).
Stenlund, A., Perricaudet, M., Tiollais, P. & Pettersson, U. Gene 10, 47–52 (1980).
Berk, A. J. & Sharp, P. A. Cell 12, 45–56 (1977).
Weinmann, R., Brendler, T. G., Raskas, H. J. & Roeder, R. G. Cell 7, 557–566 (1976).
Akusjärvi, G. & Pettersson, U. J. molec. Biol. 134, 143–158 (1979).
Zain, S., Gingeras, T. R., Bullock, P., Wong, G. & Gelinas, R. E. J. molec. Biol. 135, 413–433 (1979).
Breathnach, R., Benoist, C., O'Hare, K., Gannon, F. & Chambon, P. Proc. natn. Acad. Sci. U.S.A. 75, 4853–4857 (1978).
Lewis, J. B., Anderson, C. W. & Atkins, J. F. Cell 12, 37–44 (1977).
Kozak, M. Cell 15, 1109–1123 (1978).
Persson, H., Monstein, H-J., Akusjärvi, G. & Philipson, L. Cell 23, 485–496 (1981).
Lewis, J. B. & Mathews, M. B. Cell 21, 303–313 (1980).
Berget, S. M. & Sharp, P. A. J. molec. Biol. 129, 547–565 (1979).
Akusjärvi, G. & Persson, H. J. Virol. 38, 469–482 (1981).
Nevins, J. R. et al. J. Virol. 32, 727–733 (1979).
Shaw, A. R. & Ziff, E. B. Cell 22, 905–916 (1980).
Wilson, M. W., Nevins, J. & Darnell, J. E. Cold Spring Harb. Symp. quant. Biol. 44, 447–455 (1979).
Korn, L. J. & Brown, D. D. Cell 15, 1145–1156 (1978).
Benoist, C., O'Hare, K., Breathnach, R. & Chambon, P. Nucleic Acids Res. 8, 127–142 (1980).
Smith, M. M., Reeve, A. E. & Huang, R. C. C. Cell 15, 615–626 (1978).
Favaloro, J., Treisman, R. & Kamen, R. Meth. Enzym. (in the press).
Southern, E. M. J. molec. Biol. 98, 503–518 (1975).
McGrogan, M., Spector, D. J., Goldenberg, C. J., Halbert, D. & Raskas, H. J. Nucleic Acids Res. 6, 593–607 (1979).
Weaver, R. S. & Weismann, C. W. Nucleic Acids Res. 7, 1175–1193 (1979).
Persson, H., Pettersson, U. & Mathews, M. B. Virology 90, 67–79 (1978).
Persson, H., Jansson, M. & Philipson, L. J. molec. Biol. 137, 375–394 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Akusjärvi, G., Persson, H. Controls of RNA splicing and termination in the major late adenovirus transcription unit. Nature 292, 420–426 (1981). https://doi.org/10.1038/292420a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/292420a0
- Springer Nature Limited
This article is cited by
-
Characterization of factors involved in regulated adenovirus-2 major late pre-mRNA splicing
Molecular Biology Reports (1990)
-
Abnormal expression of a late gene family L1 protein in monkey cells abortively infected with adenovirus type 2
Virus Genes (1988)