Abstract
The dauer larva of Caenorhabditis elegans is a developmentally arrested stage induced by starvation or overcrowding. Mutant genes controlling the ability to form dauer larvae interact in a way which allows them to be ordered in a pathway. Mutant phenotypes suggest that the pathway corresponds to neural processing of environmental stimuli.
Similar content being viewed by others
References
Beadle, G. W. & Ephrussi, B. Genetics 22, 76–86 (1937).
Brenner, S. Genetics 77, 71–94 (1974).
von Ehrenstein, G. & Schierenberg, E. in Nematodes as Biological Models Vol 1 (ed. Zuckerman, B. M.) 2–71 (Academic, New York, 1980).
White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. Phil. Trans. R. Soc. B275, 327–348 (1976).
Sulston, J. E., Albertson, D. G. & Thomson, J. N. Devl Biol. 78, 542–576 (1980).
Bovien, P. Vidensk. Meddr dansk. naturh. Foren. 101, 1–113 (1937).
Cassada, R. C. & Russell, R. L. Devl Biol. 46, 326–342 (1975).
Cassada, R. C. & Russell, R. L. Fedn Proc. 33, 1476 (1974).
Klass, M. & Hirsh, D. Nature 260, 523–525 (1976).
Evans, A. A. F. & Perry, R. N. in The Organization of Nematodes (ed. Croll, N. A.) 383–424 (Academic, New York, 1976).
Albert, P. S., Brown, S. & Riddle, D. L. J. comp. Neural, (in the press).
Swanson, M. M. & Riddle, D. L. Devl Biol. (in the press).
Riddle, D. L. Stadler Genet. Symp. 9, 101–120 (1977).
Cassada, R. C. in Developmental Biology: Pattern Formation and Gene Regulation (eds McMahon, D. M. & Fox, C. F.) 539–547 (Benjamin, Menlo Park, 1975).
Lewis, J. A. & Hodgkin, J. A. J. comp. Neurol. 172, 489–510 (1977).
Ward, S. Proc. natn. Acad. Sci. U.S.A. 70, 817–821 (1973).
Ward, S., Thomson, N., White, J. G. & Brenner, S. J. comp. Neurol. 160, 313–338 (1975).
Ware, R. W., Clark, D., Grassland, K. & Russell, R. L. J. comp. Neurol. 162, 71–110 (1975).
Herman, R. K. & Horvitz, H. R. in Nematodes as Biological Models Vol 1 (ed. Zuckerman, B. M.) 228–261 (Academic, New York, 1980).
Wood, W. B., Edgar, R. S., King, J., Lielausis, I. & Henninger, M. Fedn Proc. 27, 1160–1166 (1968).
Herman, R. K., Horvitz, H. R. & Riddle, D. L. Genet. Maps 1, 183–193 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Riddle, D., Swanson, M. & Albert, P. Interacting genes in nematode dauer larva formation. Nature 290, 668–671 (1981). https://doi.org/10.1038/290668a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/290668a0
- Springer Nature Limited
This article is cited by
-
Devo-Aging: Intersections Between Development and Aging
GeroScience (2023)
-
Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons
Nature Communications (2022)
-
Molecular characterization and functional analysis of daf-8 in the pinewood nematode, Bursaphelenchus xylophilus
Journal of Forestry Research (2022)
-
LEA motifs promote desiccation tolerance in vivo
BMC Biology (2021)
-
Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans
Scientific Reports (2021)