Abstract
We have shown that the yeast Saccharomyces cerevisiae has a mechanism by which information from one gene can be transferred non-reciprocally to a repeated copy of the gene on the same chromosome. This intrachromosomal gene conversion may be important in maintaining sequence homogeneity within families of repeated eukaryotic genes.
Similar content being viewed by others
References
Petes, T. D. Cell 19, 765–774 (1980).
Szostak, J. W. & Wu, R. Nature 84, 426–430 (1980).
Tartof, K. D. Cold Spring Harb. Symp. quant. Biol. 38, 491–500 (1973).
Latt, S. A. & Schreck, R. R. Am. J. hum. Genet. 32, 297–313 (1980).
Beggs, J. D., Guerineau, M. & Atkins, J. F. Molec. gen. Genet. 148, 287–294 (1976).
Guerineau, M., Grandchamp, C. & Slonimski, P. P. Proc. natn. Acad. Sci. U.S.A. 73, 3030–3034 (1976).
Hollenberg, C. P., Degelman, A., Kustermann-Kuhn, B. & Roger, H. D. Proc natn. Acad. Sci. U.S.A. 73, 2072–2076 (1976).
Gubbins, E. J., Newlon, C. S., Kann, M. D. & Donelson, J. E. Gene 1, 185–207 (1977).
Livingston, D. M. & Klein, H. L. J. Bact. 129, 472–481 (1977).
Strathern, J., Newlon, C., Herskowitz, I. & Hicks, J. Cell 18, 309–319 (1979).
Hinnen, A., Hicks, J. & Fink, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 1929–1933 (1978).
Hicks, J., Strathern, J. & Herskowitz, I. DNA Insertion Elements, Plasmids and Episomes (eds Bukhari, A. I., Shapiro, J. A. & Adhya, S. L.) 457–462 (Cold Spring Harbor Laboratory, New York, 1977).
Klar, A. J. S. & Fogel, S. Proc. natn. Acad. Sci. U.S.A. 76, 4539–4543 (1979).
Bolivar, F. et al. Gene 2, 95–113 (1977).
Mortimer, R. K. & Hawthorne, D. C. The Yeasts Vol. I (eds Rose, A. M. & Harrison, J. S.) 286–460 (Academic, London, 1969).
Southern, E. J. molec. Biol. 98, 503–518 (1975).
Roman, H. & Jacob, F. Cold Spring Harb. Symp. quant. Biol. 23, 155–160 (1958).
Meselson, M. S. & Radding, C. N. Proc. natn. Acad. Sci. U.S.A. 72, 358–361 (1975).
Smith, G. P. Cold Spring Harb. Symp. quant. Biol. 38, 507–513 (1973).
Hood, L., Campbell, J. H. & Elgin, S. C. R. A. Rev. Genet. 9, 305–353 (1975).
Lauer, J., Shen, C. -K. J. & Maniatis, T. Cell 20, 119–130 (1980).
Zimmer, E. A., Martin, S. K., Beverly, S. M., Kan, Y. W. & Wilson, A. C. Proc. natn. Acad. Sci. U.S.A. 77, 2158–2162 (1980).
Goossens, M. et al. Proc. natn. Acad. Sci. U.S.A. 77, 518–521 (1980).
Manning, R. F. & Gage, L. P. J. biol. Chem. (in the press).
Jeffreys, A. J. Cell 18, 1–10 (1979).
Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–638 (1980).
Munz, P. & Leupold, U. Alfred Benzon Symp. 16 (in the press).
Scherer, S. & Davis, R. W. Science 209, 1380–1384 (1980).
Williamson, D. H. & Fennel, D. J. Meth. Cell Biol. 12, 335–351 (1975).
Schachat, F. W. & Hogness, D. S. Cold Spring Harb. Symp. quant. Biol. 38, 371–381 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klein, H., Petes, T. Intrachromosomal gene conversion in yeast. Nature 289, 144–148 (1981). https://doi.org/10.1038/289144a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/289144a0
- Springer Nature Limited
This article is cited by
-
Multicopy gene family evolution on primate Y chromosomes
BMC Genomics (2016)
-
Origins of multicellular evolvability in snowflake yeast
Nature Communications (2015)
-
Genome instability: a mechanistic view of its causes and consequences
Nature Reviews Genetics (2008)
-
Factors affecting ectopic gene conversion in mice
Mammalian Genome (1998)
-
Genetic evidence for different RAD52-dependent intrachromosomal recombination pathways in Saccharomyces cerevisiae
Current Genetics (1995)