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1,25-Dihydroxycholecalciferol stimulation of a mitochondrial protein in chick intestinal cells

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Abstract

The steroid hormone 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) stimulates the absorption of dietary calcium by the small intestine of animals although the exact mechanism by which this is achieved remains unclear. However, it has long been known that a soluble, calcium-binding protein (CaBP), is produced in large amounts in the cytoplasm of the intestinal cells of animals after in vivo administration of vitamin D3 or 1,25-(OH)2D3 (refs 1,2). We report here that 1,25-(OH)2D3 administered in vivo to rachitic chickens also stimulates production of another protein with molecular weight (MW) 39,000–42,000 which is insoluble in the absence of detergent, is found in the outer mitochondrial membrane and is produced in advance of maximum calcium transport.

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Authors and Affiliations

  1. Dunn Nutritional Laboratory, University of Cambridge and Medical Research Council, Milton Road, Cambridge, CB4 1XJ, UK

    Adrian N. Hobden, Marilyn Harding & D. Eric M. Lawson

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  1. Adrian N. Hobden
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  2. Marilyn Harding
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  3. D. Eric M. Lawson
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Hobden, A., Harding, M. & Lawson, D. 1,25-Dihydroxycholecalciferol stimulation of a mitochondrial protein in chick intestinal cells. Nature 288, 718–720 (1980). https://doi.org/10.1038/288718a0

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