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Moloney murine sarcoma proviral DNA is a transcriptional unit

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Abstract

A portion of Moloney murine sarcoma virus DNA which is repeated at both ends of the provirus has been sequenced. The nucleotide sequence, together with hybridization data obtained with in vitro pulse-labelled nascent viral RNA, indicate that initiation and termination of RNA synthesis occur within that region of the proviral DNA. A model for transcriptional readthrough of termination signals during RNA synthesis in this system is suggested.

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Authors and Affiliations

  1. Department of Developmental Biology and Cancer, Albert Einstein College of Medicine, Bronx, New York, 10461

    Edmund W. Benz Jr

  2. Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, 10461

    Robert M. Wydro & Bernardo Nadal-Ginard

  3. Department of Genetics and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461

    Dino Dina

Authors
  1. Edmund W. Benz Jr
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  2. Robert M. Wydro
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  3. Bernardo Nadal-Ginard
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  4. Dino Dina
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Benz, E., Wydro, R., Nadal-Ginard, B. et al. Moloney murine sarcoma proviral DNA is a transcriptional unit. Nature 288, 665–669 (1980). https://doi.org/10.1038/288665a0

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  • DOI: https://doi.org/10.1038/288665a0

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