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Highly structured water network in crystals of a deoxydinucleoside–drug complex

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Abstract

X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by networks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-Å intervals. The conformation of the deoxyribose sugar ring at the 3′ end of one strand can depend on its local aqueous environment.

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Authors and Affiliations

  1. Department of Biophysics, University of London King's College, London, WC2B 5RL, UK

    Stephen Neidle

  2. Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111

    Helen M. Berman & H. S. Shieh

Authors
  1. Stephen Neidle
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  2. Helen M. Berman
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  3. H. S. Shieh
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Neidle, S., Berman, H. & Shieh, H. Highly structured water network in crystals of a deoxydinucleoside–drug complex. Nature 288, 129–133 (1980). https://doi.org/10.1038/288129a0

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  • DOI: https://doi.org/10.1038/288129a0

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