Abstract
Somatostatin is a hypothalamic peptide hormone which inhibits growth hormone release from the anterior pituitary1. However, biochemical and morphologica1 investigations have revealed that Somatostatin is located not only in the hypothalamus but also in other brain areas (for example the cerebral cortex) where it occurs and in nerve cell bodies and fibres2–5 from which it can be released in a Ca2+-dependent manner6. It has therefore been suggested that the neuropeptide may have functions in the central nervous system other than its effect on growth hormone release7; one possible action is that of a neuromodulator4,6. Therefore, hypothalamic and cerebral cortical slices of the rat were used to examine whether Somatostatin modules the electrically or CaCl2-evoked release of tritiated monoamines from monoaminergic neurones. It is reported here that Somatostatin inhibits 3H-noradrenaline release from the hypothalamus (but not from the cerebral cortex) but does not affect the release of 3H-dopamine and 3H-serotonin.
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Göthert, M. Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones. Nature 288, 86–88 (1980). https://doi.org/10.1038/288086a0
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DOI: https://doi.org/10.1038/288086a0
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