Abstract
Lysophospholipids have been implicated in a variety of physiological processes1. In vivo lysophospholipids are invariably produced with fatty acids as the product of hydrolysis by phospholipase A2 (ref. 2). Therefore, it is of considerable interest to examine the properties of the mixture of these lipids in aqueous suspensions. Results presented here demonstrate that a mixture of fatty acid and lysophosphatidylcholine forms a bilayer type of organisation even though the individual components form micelles when dispersed in an aqueous phase.
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References
Weltzien, H. U. Biochim. biophys. Acta 559, 259–287 (1979).
Verger, R. & de Haas, G. H. A. Rev. Biophys. Bioengng 5, 77–117 (1976).
Jain, M. K. & Wu, N. M. J. Membrane Biol. 34, 157–201 (1977).
Ververgaert, P. H. J., Elbers, P. F., Luitingh, A. J. & van den Bergh, H. J. Cytobiology 6, 86–96 (1972).
Klopfenstein, W. E., de Kruyff, B., Verkleij, A. J., Demel, R. A. & van Deenen, L. L. M. Chem. Phys. Lipids 13, 215–222 (1974).
van Echteld, C. J. A., de Kruyff, B. & de Gier, J. Biochim. biophys. Acta 595, 71–81 (1980).
Cullis, P. R. & de Kruyff, B. Biochim. biophys. Acta 507, 207–218 (1978).
Jain, M. K. & White, H. B. Adv. Lipid Res. 15, 1–60 (1977).
Jain, M. K., Ramirez, F., McCaftrey, T. M., Ioannou, P. V. & Marecek, J. F. Biochim. biophys. Acta (submitted).
de Oliveira Filgueiras, O. M., van den Besselaar, A. M. H. P. & van den Bosch, H. Biochim. biophys. Acta 58, 73–84 (1979).
Wilschut, J. C., Regts, J. & Scherphof, G. FEBS Lett. 98, 181–186 (1979).
Zwaal, R. F. A., Roelofsen, B., Comfurius, P. & van Deenen, L .L. M. Biochim. biophys. Acta 406, 83–96 (1975).
van Meer, G., de Kruyff, B., Op den Kamp, J. A. F. & van Deenen, L. L. M. Biochim. biophys. Acta 596, 1–9 (1980).
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Jain, M., van Echteld, ., Ramirez, . et al. Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers. Nature 284, 486–487 (1980). https://doi.org/10.1038/284486a0
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DOI: https://doi.org/10.1038/284486a0
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