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Ca2+-dependent hormonal stimulation of ciliary activity

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Abstract

It has been demonstrated that calcium modulates ciliary activity in protozoa1 and also in epithelial cilia of the mussel gill2. Changes in the frequency of ciliary beat in the oviduct of the salamander have also been associated with movement of Ca2+ across the cell membrane3. However, the control of ciliary activity in mammals is poorly understood and the function of calcium in mammalian cilia and its role in coupling hormonal effects to changes in ciliary activity have been only preliminarily investigated4. The evidence presented here suggests that the stimulus–response coupling of the stimulating effect of prostaglandin E2 (PGE2) on ciliary activity of the rabbit oviduct is carried out by release of intracellular Ca2+.

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References

  1. Murakami, A. & Eckert, R. Science 175, 1375–1377 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Satir, R., Reed, W. & Wolf, D. I. Nature 263, 520–521 (1976).

    Article  ADS  CAS  Google Scholar 

  3. Eckert, R. & Murakami, A. J. Physiol, Lond. 226, 699–711 (1972).

    Article  CAS  Google Scholar 

  4. Verdugo, P., Lee, W. I., Rumery, R. E. & Tam, P. Y. Biophys. J. 16, 120a (1976).

    Google Scholar 

  5. Rumery, R. E., Phinney, E. & Blandau, R. J. in Methods in Mammalian Embryology (ed. Daniel, J.C. Jr) 472–795 (Freeman, San Francisco, 1970).

    Google Scholar 

  6. Lee, W. I. & Verdugo, P. Biophys. J. 16, 1115–1119 (1976).

    Article  ADS  CAS  Google Scholar 

  7. Verdugo, P., Rumery, R. E. & Lee, W. I. J. Cell Biol. 75, 293a (1977).

    Google Scholar 

  8. Huxley, H. E. Nature 243, 445–449 (1973).

    Article  ADS  CAS  Google Scholar 

  9. Naitoh, Y. & Kaneko, H. J. exp. Biol. 58, 657–676 (1973).

    CAS  Google Scholar 

  10. Rubin, R. P. Calcium and the Secretory Process (Plenum, New York, 1974).

    Book  Google Scholar 

  11. Horton, E. W. Physiol. Rev. 49, 122–161 (1969).

    Article  CAS  Google Scholar 

  12. Kirtland, S. J. & Baum, H. Nature new Biol. 236, 47–49 (1972).

    Article  CAS  Google Scholar 

  13. Spilman, C. H. in Ovum Transport and Fertility Regulation (ed. Harper, M. J. K.) 197–211 (Scriptor, Copenhagen, 1975).

    Google Scholar 

  14. Verdugo, P., Blandau, R. J., Tam, P. Y. & Halbert, S. A. in Ovum Transport and Fertility Regulation (ed. Harper, M. J. K.) 126–137 (Scriptor, Copenhagen, 1975).

    Google Scholar 

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Authors and Affiliations

  1. Center for Bioengineering and Department of Biological Structure, University of Washington, Seattle, Washington, 98195

    Pedro Verdugo

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  1. Pedro Verdugo
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Verdugo, P. Ca2+-dependent hormonal stimulation of ciliary activity. Nature 283, 764–765 (1980). https://doi.org/10.1038/283764a0

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