Skip to main content
SpringerLink
Log in

Histone H5 messenger RNA is polyadenylated

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

In most known systems1,2, histone mRNA lacks the poly(A) sequence at the 3′ end of the molecule typical of most mRNAs. Furthermore, the synthesis of histones, unlike that of most proteins, is tightly coupled to DNA synthesis3–5. Nevertheless, histone synthesis occurs in amphibian oocytes in the absence of DNA synthesis6. Moreover, it has recently been found that in amphibian oocytes most of the histone mRNA is polyadenylated7–9, and the polyadenylate is probably removed during maturation of the oocyte10. Histone H5, an H1-like tissue-specific histone occurring only in nucleated erythrocytes11, is also atypical in that it is synthesised in the absence of DNA synthesis during maturation of the red blood cells12,13. We report here that H5 mRNA is polyadenylated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adesnik, M. & Darnell, J. E. J. molec. Biol. 67, 397–406 (1972).

    Article  CAS  Google Scholar 

  2. Grunstein, M., Levy, S., Schedl, P. & Kedes, L. Cold Spring Harb. Sym. quant. Biol. 38, 717–724 (1973).

    Article  Google Scholar 

  3. Borum, T. W., Scharff, M. D. & Robbins, E. Proc. nat. Acad. Sci. U.S.A. 58, 1977–1983 (1967).

    Article  ADS  Google Scholar 

  4. Perry, R. P. & Kelly, D. E. J. molec. Biol. 799, 681–696 (1973).

    Article  Google Scholar 

  5. Stahl, H. & Gallwitz, D. Eur. J. Biochem. 72, 385–392 (1977).

    Article  CAS  Google Scholar 

  6. Adamson, F. D. & Woodland, H. R. J. molec. Biol. 88, 263–285 (1974).

    Article  CAS  Google Scholar 

  7. Levenson, R. G. & Marcu, K. B. Cell 9, 311–322 (1976).

    Article  CAS  Google Scholar 

  8. Ruderman, J. V. & Pardue, M. L. Devl Biol. 60, 48–68 (1977).

    Article  CAS  Google Scholar 

  9. Ruderman, J. V. & Pardue, M. L. J. biol. Chem. 253, 2018–2025 (1978).

    CAS  PubMed  Google Scholar 

  10. Ruderman, J. V., Woodland, H. R. & Sturgess, E. A. Devl Biol. 71, 71–82 (1979).

    Article  CAS  Google Scholar 

  11. Neelin, J. M., Callahan, P. X., Lamb, D. C. & Murray, K. Can. J. Biochem. 42, 1743–1752 (1964).

    Article  CAS  Google Scholar 

  12. Appels, R. & Wells, J. R. E. J. molec. Biol. 70, 425–434 (1972).

    Article  CAS  Google Scholar 

  13. Ruiz-Carrillo, A., Wangh, L. J. & Allfrey, V. G. Archs Biochem. Biophys. 174, 273–290 (1976).

    Article  CAS  Google Scholar 

  14. Perucho, M., Molgaard, H. V., Pataryas, T., Shevack, A. & Ruiz-Carrillo, A. Analyt. Biochem. 98, 464–471 (1979).

    Article  CAS  Google Scholar 

  15. Groner, B. et al. J. biol. Chem. 252, 6666–6674 (1977).

    CAS  PubMed  Google Scholar 

  16. Scott, A. C. & Wells, J. R. E. Nature 259, 635–638 (1976).

    Article  ADS  CAS  Google Scholar 

  17. Johns, E. W. Biochem. J. 92, 55–59 (1964).

    Article  CAS  Google Scholar 

  18. Crawford, R. J., Scott, A. C. & Wells, J. R. E. Eur. J. Biochem. 72, 291–299 (1977).

    Article  CAS  Google Scholar 

  19. Longacre, S. S. & Rutter, W. J. J. biol. Chem. 252, 2742–2752 (1977).

    CAS  PubMed  Google Scholar 

  20. Brownlee, G. G., Cartwright, E. M., Cowan, N. J., Jarvis, J. M. & Milstein, C. Nature new Biol. 244, 236–239 (1973).

    Article  CAS  Google Scholar 

  21. Perry, R. P., La Torre, J., Kelley, D. E. & Greenberg, J. R. Biochem. biophys. Acta 262, 220–226 (1972).

    CAS  PubMed  Google Scholar 

  22. Adesnik, M., Salditt, M., Thomas, W. & Darnell, J. E. J. molec. Biol. 71, 21–30 (1972).

    Article  CAS  Google Scholar 

  23. Ruiz-Carrillo, A. & Jorcano, J. L. Biochemistry 18, 760–768 (1979).

    Article  CAS  Google Scholar 

  24. Bonner, W. M. & Laskey, R. A. Eur. J. Biochem. 46, 83–88 (1974).

    Article  CAS  Google Scholar 

  25. Laskey, R. A. & Mills, A. D. Eur. J. Biochem. 56, 335–341 (1975).

    Article  CAS  Google Scholar 

  26. Rice, R. H. & Means, G. E. J. biol. Chem. 246, 831–832 (1971).

    CAS  PubMed  Google Scholar 

  27. Pinder, J. C., Staynov, D. Z. & Gratzer, W. B. Biochemistry 13, 5373–5378 (1974).

    Article  CAS  Google Scholar 

  28. Burckhardt, J. & Birnstiel, M. L. J. molec. Biol. 118, 61–79 (1978).

    Article  CAS  Google Scholar 

  29. Bishop, J. O., Rosbash, M. & Evans, D. J. molec. Biol. 85, 75–86 (1974).

    Article  CAS  Google Scholar 

  30. Sautière, P. et al. FEBS Lett. 63, 164–166 (1976).

    Article  Google Scholar 

  31. Scott, A. C. & Wells, J. R. E. Biochem. biophys. Res. Commun. 64, 448–455 (1975).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. H. V. Molgaard

    Present address: King's College, Department of Biophysics, University of London, WC2, UK

  2. M. Perucho

    Present address: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724

Authors and Affiliations

  1. Max-Planck-Institut für Molekulare Genetik, D-1000, Berlin, 33, Ihnestr. 63–73, FRG

    H. V. Molgaard, M. Perucho & A. Ruiz-Carrillo

Authors
  1. H. V. Molgaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Perucho
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Ruiz-Carrillo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Molgaard, H., Perucho, M. & Ruiz-Carrillo, A. Histone H5 messenger RNA is polyadenylated. Nature 283, 502–504 (1980). https://doi.org/10.1038/283502a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/283502a0

  • Springer Nature Limited

This article is cited by

Search

Navigation