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Equilibrium: the intracellular distribution of steroid receptors

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Abstract

Data are presented which suggest that there are unbound receptors for oestrogen in nuclei of the smooth muscle cells of the myometrium. A new model for the distribution of unbound receptors is proposed in which unbound receptor is in equilibrium, partitioned between nucleus and cytoplasm according to the free water content of these intracellular compartments.

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Authors and Affiliations

  1. Department of Anatomy, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, 78284

    Peter J. Sheridan, James M. Buchanan & Vincent C. Anselmo

  2. Laboratoire Recepteurs Hormonaux, Institut Paoli Calmette, Marseilles, France

    Pierre M. Martin

Authors
  1. Peter J. Sheridan
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  2. James M. Buchanan
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  3. Vincent C. Anselmo
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  4. Pierre M. Martin
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Sheridan, P., Buchanan, J., Anselmo, V. et al. Equilibrium: the intracellular distribution of steroid receptors. Nature 282, 579–582 (1979). https://doi.org/10.1038/282579a0

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  • DOI: https://doi.org/10.1038/282579a0

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