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Bombesin suppresses feeding in rats

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Abstract

Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like irnmunoactivity is widely distributed in mammalian gut2–5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7–9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.

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References

  1. Erspamer, V. & Melchiorri, P. Pure appl. Chem. 35, 463–494 (1973).

    Article  CAS  Google Scholar 

  2. Walsh, J. H. & Holmquist, A. L. Gastroenterology 70, A-90/948 (1976).

  3. Polak, J. M., Bloom, S. R., Hobbs, S., Solcia, E. & Pearse, A. G. E. Lancet i, 1109–1110 (1976).

    Article  Google Scholar 

  4. Walsh, J. H. & Dockray, G. J. Gastroenterology 74, 1108 (1978).

    Google Scholar 

  5. Brown, M., Allen, R., Villarreal, J., Rivier, J. & Vale, W. Life Sci. 23, 2721–2728 (1978).

    Article  CAS  Google Scholar 

  6. Erspamer, V. & Melchiorri, P. J. Endocr. 70, 12P–13P (1976).

    CAS  PubMed  Google Scholar 

  7. Gibbs, J., Young, R. C. & Smith, G. P. J. comp. Physiol. Psychol. 84, 488–495 (1973).

    Article  CAS  Google Scholar 

  8. Gibbs, J., Falasco, J. D. & McHugh, P. R. Am. J. Physiol. 230, 15–18 (1976).

    CAS  PubMed  Google Scholar 

  9. Gibbs, J. & Smith, G. P. Acta hepato-gastroenterol. 25, 413–416 (1978).

    CAS  Google Scholar 

  10. Erspamer, V. & Melchiorri, P. in Gastrointestinal Hormones (ed. Thompson, J. C.) 575–589 (University of Texas Press, Austin, 1975).

    Google Scholar 

  11. Basso, N. et al. Gut 16, 994–998 (1975).

    Article  CAS  Google Scholar 

  12. Antin, J., Gibbs, J., Holt, J., Young, R. C. & Smith, G. P. J. comp. Physiol. Psychol. 89, 784–790, 1975.

    Article  CAS  Google Scholar 

  13. Brown, M., Rivier, J. & Vale, W. Science 196, 998–1000 (1977).

    Article  ADS  CAS  Google Scholar 

  14. Goldstein, A., Aronow, L. & Kalman, S. M. Principles of Drug Action: The Basis of Pharmacology, 79, (Harper and Row, New York, 1968).

    Google Scholar 

  15. Konturek, S. J., Krol, R. & Tasler, J. J. Physiol., Lond. 257, 663–672 (1976).

    Article  CAS  Google Scholar 

  16. Fender, H. R., Curtis, P. J., Rayford, P. L. & Thompson, J. C. Surg. Forum 37, 414–416 (1976).

    Google Scholar 

  17. Miyata, M., Guzman, S., Raymond, P. L. & Thompson, J. C. Gastroenterology 74, 1137 (1978).

    Google Scholar 

  18. Linari, G., Baldieri Linari, M. & Lutoslawska, G. Rc. Gastroenterol. 9, 179–184 (1977).

    CAS  Google Scholar 

  19. Deschodt-Lanckman, M., Robberecht, P., De Neef, P., Lammens, M. & Christophe, J. J. clin. Invest. 58, 891–898 (1976).

    Article  CAS  Google Scholar 

  20. Iwatsuki, N. & Petersen, O. H. J. clin. Invest. 61, 41–46 (1978).

    Article  CAS  Google Scholar 

  21. May, R. J., Conlon, T. P., Erspamer, V. & Gardner, J. D. Am. J. Physiol. 235, E112–E118 (1978).

    CAS  PubMed  Google Scholar 

  22. Kraly, F. S. & Smith, G. P. Physiol. Behav. 21, 405–408 (1978).

    Article  CAS  Google Scholar 

  23. Deutsch, J. A., Young, W. G. & Kalogeris, T. J. Science 201, 165–167 (1978).

    Article  ADS  CAS  Google Scholar 

  24. Kraly, F. S. & Gibbs, J. Abstr. Soc. Neurosci. 4, 176, (1978).

    Google Scholar 

  25. Villarreal, J. A. & Brown, M. R. Life Sci. 23, 2729–2734 (1978).

    Article  CAS  Google Scholar 

  26. Dockray, G. J. Nature 264, 568–570 (1976).

    Article  ADS  CAS  Google Scholar 

  27. Straus, E., Muller, J. E., Choi, H. S., Paronetto, F. & Yalow, R. S. Proc. natn. Acad. Sci. U.S.A. 74, 3033–3034 (1977).

    Article  ADS  CAS  Google Scholar 

  28. Muller, J. E., Straus, E. & Yalow, R. S. Proc. natn. Acad. Sci. U.S.A. 74, 3035–3037 (1977).

    Article  ADS  CAS  Google Scholar 

  29. Rehfeld, J. J. biol. Chem. 253, 4022–4030 (1978).

    CAS  PubMed  Google Scholar 

  30. Innis, R. B., Correa, F. M. A., Uhl, G. R., Schneider, B. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 76, 521–525 (1979).

    Article  ADS  CAS  Google Scholar 

  31. Goldstein, A. Biostatistics: An Introductory Text, 144 (Macmillan, New York, 1964).

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, Cornell University Medical College, Bourne Laboratory, The New York Hospital, White Plains, New York, 10605

    J. Gibbs & D. J. Fauser

  2. Department of Experimental Psychology, University of Oxford, Oxford, UK

    E. A. Rowe, B. J. Rolls, E. T. Rolls & S. P. Maddison

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  1. J. Gibbs
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  2. D. J. Fauser
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  3. E. A. Rowe
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  4. B. J. Rolls
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  5. E. T. Rolls
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  6. S. P. Maddison
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Gibbs, J., Fauser, D., Rowe, E. et al. Bombesin suppresses feeding in rats. Nature 282, 208–210 (1979). https://doi.org/10.1038/282208a0

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