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Ca2+-sensitive gelation of actin filaments by a new protein factor

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Abstract

Two protein factors which bind to, and induce gelation of, actin filaments were purified from Ehrlich tumour cells. Filamin induced Ca2+-insensitive gelation, whereas a new protein factor (‘actinogelin’) was found to induce Ca2+-sensitive gelation.

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References

  1. Pollard, T. D. J. Cell Biol. 68, 579–601 (1976).

    Article  CAS  Google Scholar 

  2. Maruta, H. & Korn, E. D. J. biol. Chem 252, 399–402 (1977).

    CAS  PubMed  Google Scholar 

  3. Condeelis, J. S. & Taylor, D. L. J. Cell Biol. 74, 901–927 (1977).

    Article  CAS  Google Scholar 

  4. Stossel, T. P. & Hartwig, J. A. J. Cell Biol. 68, 602–619 (1976).

    Article  CAS  Google Scholar 

  5. Weihing, R. R. J. Cell Biol. 71, 303–307 (1976).

    Article  CAS  Google Scholar 

  6. Mirura, N. & Asano, A. Nature 272, 273–276 (1978).

    Article  ADS  Google Scholar 

  7. Kane, R. E. J. Cell Biol. 71, 704–714 (1976).

    Article  CAS  Google Scholar 

  8. Taylor, D. L. Expl Cell Res. 105, 413–426 (1977).

    Article  CAS  Google Scholar 

  9. Nacchache, P. H., Volpi, M., Showell, H. J., Becker, E. L. & Sha'afi, R. I. Science 203, 461–463 (1979).

    Article  ADS  Google Scholar 

  10. Theoharides, T. C. & Douglas, W.W. Science 201, 1143–1145 (1978).

    Article  ADS  CAS  Google Scholar 

  11. Rahamimoff, R., Meiri, H., Erulkar, S. D. & Barenholz, Y. Proc. natn. Acad. Sci. U.S.A. 75, 5214–5216 (1978).

    Article  ADS  CAS  Google Scholar 

  12. Fulton, B. P. & Whitlingham, D. G. Nature 273, 149–151 (1978).

    Article  ADS  CAS  Google Scholar 

  13. Clark, T. G. & Merrian, R. W. J. Cell Biol. 77, 427–438 (1978).

    Article  CAS  Google Scholar 

  14. Okada, Y. & Murayama, F. Expl Cell Res. 44, 527–551 (1966).

    Article  CAS  Google Scholar 

  15. Ohki, K., Asano, A. & Okada, Y. Biochim. biophys. Acta 507, 507–516 (1978).

    Article  CAS  Google Scholar 

  16. Volsky, D. J. & Loyter, A. J. Cell Biol. 78, 465–479 (1978).

    Article  CAS  Google Scholar 

  17. Blow, A. M. J. et al. FEBS Lett. 94, 305–310 (1978).

    Article  CAS  Google Scholar 

  18. Shainberg, A., Yagil, G. & Yafe, D. Devl Biol. 25, 1–29 (1971).

    Article  CAS  Google Scholar 

  19. Shizuta, Y. et al. J. biol. Chem. 251, 6562–6567 (1976).

    CAS  PubMed  Google Scholar 

  20. Wang, K. Biochemistry 16, 1857–1865 (1977).

    Article  CAS  Google Scholar 

  21. Brotschi, E., Hartwig, J. H. & Stossel, T. P. J. biol. Chem. 253, 8988–8993 (1978).

    CAS  PubMed  Google Scholar 

  22. Bryan, J. & Kane, R. E. J. molec. Biol. 125, 207–224 (1978).

    Article  CAS  Google Scholar 

  23. Yin, H. L. & Stossel, T. P. J. Cell Biol. 79, 271a (1978).

    Google Scholar 

  24. Virgin, H. W., Hellewell, S. B. & Taylor, D. L. J. Cell Biol. 79, 265a (1978).

    Google Scholar 

  25. Weihing, R. R. J. Cell Biol. 75, 95–103 (1977).

    Article  CAS  Google Scholar 

  26. Boxer, L. A. & Stossel, T. P. J. clin. Invest. 57, 964–976 (1976).

    Article  CAS  Google Scholar 

  27. Davies, P. J. A. et al. J. biol. Chem. 253, 4036–4042 (1978).

    CAS  PubMed  Google Scholar 

  28. Kakiuchi, S., Yamazaki, R., Teshima, Y., Uenishi, K. & Miyamoto, E. Proc. natn. Acad. Sci. U.S.A. 70, 3526–3530 (1973).

    Article  ADS  CAS  Google Scholar 

  29. Lin, Y. M., Lin, Y. P. & Cheung, W. Y. J. biol. Chem. 249, 4943–4954 (1974).

    CAS  PubMed  Google Scholar 

  30. Mikawa, T., Nonomura, Y., Hirata, M., Ebashi, S. & Kakiuchi, S. J. Biochem. (Tokyo) 84, 1633–1636 (1978).

    Article  CAS  Google Scholar 

  31. Davies, P., Bechtel, P. & Pastan, I. FEBS Lett. 77, 228–232 (1977).

    Article  CAS  Google Scholar 

  32. Moore, P. B. & Carraway, K. L. Biochem. biophys. Res. Commun. 80, 560–567 (1978).

    Article  CAS  Google Scholar 

  33. Lazarides, E. J. Cell Biol. 68, 202–209 (1976).

    Article  CAS  Google Scholar 

  34. Maruyama, K. & Ebashi, S. J. Biochem. (Tokyo) 58, 13–19 (1965).

    Article  CAS  Google Scholar 

  35. Briskey, E. J., Seraydarian, K. & Mommerts, W. F. H. M. Biochim. biophys. Acta 133, 424–434 (1967).

    Article  CAS  Google Scholar 

  36. Ishiwata, S. Biochim. biophys. Acta 303, 77–89 (1973).

    Article  CAS  Google Scholar 

  37. Ishiwata, S. Biochim. biophys. Acta 534, 350–357 (1978).

    Article  CAS  Google Scholar 

  38. Spudich, J. A., Mockrin, S. C., Brown, S. S., Rubenstein, P. A. & Levinson, W. in Cell Shape and Surface Architecture (eds Revel, J. P., Henning, U. & Fox, C. F.) 545–558 (Liss, New York, 1977).

    Google Scholar 

  39. Griffith, L. M. & Pollard, T. D. J. Cell Biol. 78, 958–965 (1978).

    Article  CAS  Google Scholar 

  40. Schook, W., Puszikin, S., Bloom, W., Ores, C. & Kochwa, S. Proc. natn. Acad. Sci. U.S.A. 76, 116–120 (1979).

    Article  ADS  CAS  Google Scholar 

  41. Korn, E. D. Proc. natn. Acad. Sci. U.S.A. 75, 588–599 (1978).

    Article  ADS  CAS  Google Scholar 

  42. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. J. biol. Chem. 193, 265–275 (1951).

    CAS  Google Scholar 

  43. Ogawa, Y. J. Biochem. (Tokyo) 64, 255–257 (1968).

    Article  CAS  Google Scholar 

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Mimura, N., Asano, A. Ca2+-sensitive gelation of actin filaments by a new protein factor. Nature 282, 44–48 (1979). https://doi.org/10.1038/282044a0

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  • DOI: https://doi.org/10.1038/282044a0

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