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The amino acid sequence of the α-chain of human fibrinogen

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Abstract

The amino acid sequence of the human fibrinogen α-chain reveals a structure that can be divided into three zones of unique amino acid composition. The middle of these contains the two primary α-chain cross-linking acceptor sites and consists of a remarkable series of internal duplications.

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Authors and Affiliations

  1. Department of Chemistry, University of California, San Diego, La Jolla, California, 92093

    R. F. Doolittle, K. W. K. Watt, B. A. Cottrell, D. D. Strong & M. Riley

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  1. R. F. Doolittle
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  2. K. W. K. Watt
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  3. B. A. Cottrell
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  4. D. D. Strong
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  5. M. Riley
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Doolittle, R., Watt, K., Cottrell, B. et al. The amino acid sequence of the α-chain of human fibrinogen. Nature 280, 464–468 (1979). https://doi.org/10.1038/280464a0

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