Skip to main content
SpringerLink
Log in

Toward a molecular biology of memory: the light's coming on!

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Abstract

Transgenic mice with a CREB-dependent reporter gene are used to show that contextual fear conditioning activates CRE-mediated transcription in CA1 of the hippocampus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Summary of the CREB pathway that has been implicated in long-term memory formation.
Figure 2: CREB-mediated transcription occurs when an associative memory forms in the hippocampus.

References

  1. Tully, T. Proc. Natl. Acad. Sci. USA 94, 4239– 4241 (1997).

    Article  CAS  Google Scholar 

  2. Impey, S. et al. Neuron 16, 973–982 (1996).

    Article  CAS  Google Scholar 

  3. Dubnau, J. & Tully, T. Ann. Rev. Neurosci. 21 , 407–444 (1998).

    Article  CAS  Google Scholar 

  4. Bourtchuladze, R. et al. Cell 79, 59–68 (1994).

    Article  CAS  Google Scholar 

  5. Gass, P. et al. Learn Mem.(in press).

  6. Kogan, J.H. et al. Curr. Biol. 7, 1–11 (1997).

    Article  CAS  Google Scholar 

  7. Merzenich, M. M. et al. Science 271, 77–81 (1996).

    Article  CAS  Google Scholar 

  8. Guzowski, J. F. & McGaugh, J. L. Proc. Natl. Acad. Sci. USA 94, 2693–2698 (1997).

    Article  CAS  Google Scholar 

  9. Lamprecht, R., Hazvi, S. & Dudai, Y. J. Neurosci. 17, 8443– 8450 (1997).

    Article  CAS  Google Scholar 

  10. Bartsch, D. et al. Cell 83, 956–992 (1995).

    Article  Google Scholar 

  11. Abel, T. & Kandel, E. Brain Res. Rev. 26, 360–378 (1998).

    Article  CAS  Google Scholar 

  12. Deisseroth, K., Heist, E. K. & Tsien, R. W. Nature 392, 198– 202 (1998).

    Article  CAS  Google Scholar 

  13. Chawla, S., Hardingham, G. E., Quinn, D. R. & Bading, H. Science 281, 1505–1509 ( 1998).

    Article  CAS  Google Scholar 

  14. Crino, P. et al. Proc. Natl. Acad. Sci USA 95, 2313– 2318 (1998).

    Article  CAS  Google Scholar 

  15. Nedivi, E., Wu, G.-Y. & Cline, H. T. Science 281, 1863– 1866 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, 11724, New York, USA

    Tim Tully

Authors
  1. Tim Tully
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tully, T. Toward a molecular biology of memory: the light's coming on!. Nat Neurosci 1, 543–545 (1998). https://doi.org/10.1038/2780

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2780

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation