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Normal human tissues contain RNA and antigens related to infectious adenovirus type 2

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Abstract

Normal human tissues have been found to contain RNA which hybridises with four regions of the adenovirus type 2 genome, including one which contains the transforming gene(s) of this virus. The RNAs have also been extracted from gorilla organs, but not from those of chickens, suggesting that they are a feature of all normal higher primate tissues. Serological tests suggest that these homologous RNAs are translated into proteins connected with essentially normal and virus-infected cell functions.

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References

  1. Rowe, W. P., Huebner, R. J., Gillmore, L. K., Parrot, R. H. & Ward, T. G. Proc. Soc. exp. Biol. Med. 84, 570 (1953).

    Article  CAS  Google Scholar 

  2. Hilleman, M. R. & Werner, J. H. Proc. Soc. exp. Biol. Med. 85, 183 (1954).

    Article  CAS  Google Scholar 

  3. Trentin, J. J., Yabe, Y. & Taylor, G. Science 137, 835 (1962).

    Article  ADS  CAS  Google Scholar 

  4. Huebner, R. J., Rowe, W. P., Turner, H. C. & Dane, W. T. Proc. natn. Acad. Sci. U.S.A. 50, 379 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Rabson, A. S., Kirschstein, R. L. & Paul, F. J. J. natn. Cancer Inst. 32, 87 (1964).

    Google Scholar 

  6. Yabe, Y., Samper, L., Bryan, E., Taylor, G. & Trentin, J. J. Science 143, 46 (1964).

    Article  ADS  CAS  Google Scholar 

  7. Graham, F. L. et al. Cold Spring Harb. Symp. quant. Biol. 39, 639 (1974).

    Article  Google Scholar 

  8. Moar, M. H. & Jones, K. W. Int. J. Cancer 16, 998 (1975).

    Article  CAS  Google Scholar 

  9. John, H. A., Patrinou-Georgoulas, M. & Jones, K. W. Cell 12, 501 (1977).

    Article  CAS  Google Scholar 

  10. Jones, K. W., Fenoglio, C. M., Shevchuk-Chaban, M., Maitland, N. & McDougall, J. M. in Oncogenesis and Herpes viruses 3 (Int. Agency Res. Cancer, Lyon, 1978).

    Google Scholar 

  11. Graham, F. L., Van Der Eb, A. J. & Heijneker, H. L. Nature 251, 687 (1974).

    Article  ADS  CAS  Google Scholar 

  12. Gallimore, P. H., Sharp, P. A. & Sambrook, J. J. molec. Biol. 89, 49 (1974).

    Article  CAS  Google Scholar 

  13. Stehelin, D., Varmus, H. E., Bishop, J. M. & Vogt, P. K. Nature 260, 170 (1976).

    Article  ADS  CAS  Google Scholar 

  14. Spector, D. H. et al. Cell 13, 371 (1978).

    Article  CAS  Google Scholar 

  15. Todaro, G. J. & Huebner, R. J. Proc. natn. Acad. Sci. U.S.A. 69, 1009 (1972).

    Article  ADS  CAS  Google Scholar 

  16. Steeves, R. & Lilly, F. A. Rev. Genet. II, 277 (1977).

    Article  Google Scholar 

  17. Chattopadhyam, S. K., Rowe, W. P., Teich, N. M. & Lowy, D. R. Proc. natn. Acad. Sci. U.S.A. 72, 906 (1975).

    Article  ADS  Google Scholar 

  18. Craig, E. A., Zimmer, S. & Raskas, H. J. J. Virol. 15, 1202 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Commerford, S. L. Biochemistry 10, 1993 (1971).

    Article  CAS  Google Scholar 

  20. Gillespie, D. & Spiegelman, S. J. molec. Biol. 12, 289 (1965).

    Article  Google Scholar 

  21. Southern, E. M. J. molec. Biol. 98, 503 (1975).

    Article  CAS  Google Scholar 

  22. Flint, J. Cell 10, 153 (1977).

    Article  CAS  Google Scholar 

  23. Berk, A. J. & Sharp, P. A. Cell 14, 695 (1978).

    Article  CAS  Google Scholar 

  24. Strand, M. & August, J. T. Proc. natn. Acad. Sci. U.S.A. 74, 2729 (1977).

    Article  ADS  CAS  Google Scholar 

  25. Klessig, D. F. Cell 12, 9 (1977).

    Article  CAS  Google Scholar 

  26. Berk, A. J. & Sharp, P. A. Cell 12, 45 (1977).

    Article  CAS  Google Scholar 

  27. Klein, G. in The Herpesviruses, ch 16 (ed. Kaplan, A. S.) (Academic, New York, 1973).

    Google Scholar 

  28. Jones, N. & Shenk, T. Cell 13, 181 (1978).

    Article  CAS  Google Scholar 

  29. Berk, A. J. & Sharp, P. A. Cell 14, 695 (1978).

    Article  CAS  Google Scholar 

  30. Mak, S. & Green, M. J. Virol. 2, 1055 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Pina, M. & Green, M. Proc. natn. Acad. Sci. U.S.A. 54, 547 (1965).

    Article  ADS  CAS  Google Scholar 

  32. Kato, K. J. natn. Cancer Inst. 58, 259 (1977).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Animal Genetics, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, UK

    K. W. Jones, J. Kinross & N. Maitland

  2. Department of Bacteriology, Medical School, University of Edinburgh, Edinburgh, UK

    M. Norval

Authors
  1. K. W. Jones
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  2. J. Kinross
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  3. N. Maitland
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  4. M. Norval
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Jones, K., Kinross, J., Maitland, N. et al. Normal human tissues contain RNA and antigens related to infectious adenovirus type 2. Nature 277, 274–279 (1979). https://doi.org/10.1038/277274a0

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  • DOI: https://doi.org/10.1038/277274a0

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