Skip to main content
SpringerLink
Log in

Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

A fragment of HeLa cell mitochondrial DNA containing the origin of replication has been sequenced. The precise position of the origin in this sequence has been identified by determining the nucleotide order in the 5′-end proximal portion of the heavy strand initiation fragment (7S DNA), and by aligning the two sequences.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Robberson, D. L., Kasamatsu, H. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 69, 737–741 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Robberson, D. L. & Clayton, D. A. Proc. natn. Acad. Sci. U.S.A. 69, 3810–3814 (1972).

    Article  ADS  CAS  Google Scholar 

  3. Kasamatsu, H. & Vinograd, J. A. Rev. Biochem. 43, 695–719 (1974).

    Article  CAS  Google Scholar 

  4. Wolstenholme, D. R., Koike, K. & Cochran-Fouts, P. J. Cell Biol. 56, 230–245 (1973).

    Article  CAS  Google Scholar 

  5. Matsumoto, L., Kasamatsu, H., Piko, L. & Vinograd, J. J. Cell Biol. 63, 146–159 (1974).

    Article  CAS  Google Scholar 

  6. Rubenstein, J. L. R., Brutlag, D. & Clayton, D. A. Cell 12, 471–482 (1977).

    Article  CAS  Google Scholar 

  7. Kasamatsu, H., Robberson, D. L. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 68, 2252–2257 (1971).

    Article  ADS  CAS  Google Scholar 

  8. Gillum, A. M. & Clayton, D. A. Proc. natn. Acad. Sci. U.S.A. 75, 677–681 (1978).

    Article  ADS  CAS  Google Scholar 

  9. Brown, W. M., Shine, J. & Goodman, H. M. Proc. natn. Acad. Sci. U.S.A. 75, 735–739 (1978).

    Article  ADS  CAS  Google Scholar 

  10. Bogenhagen, D. & Clayton, D. A. J. molec. Biol. 119, 49–68 (1978).

    Article  CAS  Google Scholar 

  11. Albring, M., Griffith, J. & Attardi, G. Proc. natn. Acad. Sci. U.S.A. 74, 1348–1352 (1977).

    Article  ADS  CAS  Google Scholar 

  12. Ojala, D. & Attardi, G. Plasmid 1, 78–105 (1977).

    Article  CAS  Google Scholar 

  13. Ojala, D. & Attardi, G. J. molec. Biol. 122, 301–319 (1978).

    Article  CAS  Google Scholar 

  14. Brown, W. M. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 71, 4617–4621 (1974).

    Article  ADS  CAS  Google Scholar 

  15. Angerer, L., Davidson, N., Murphy, W., Lynch, D. & Attardi, G. Cell 9, 81–90 (1976).

    Article  CAS  Google Scholar 

  16. Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).

    Article  ADS  CAS  Google Scholar 

  17. Van de Sande, J. H., Kleppe, K. & Khorana, H. G. Biochemistry 12, 5050–5055 (1973).

    Article  CAS  Google Scholar 

  18. Berkner, K. L. & Folk, W. R. J. biol. Chem. 252, 3176–3184 (1977).

    CAS  PubMed  Google Scholar 

  19. Efstratiadis, A., Kafatos, F. C. & Maniatis, T. Cell 10, 571–585 (1977).

    Article  CAS  Google Scholar 

  20. Simoncsits, A., Brownlee, G. G., Brown, R. S., Rubin, J. R. & Guilley, H. Nature 269, 833–836 (1977).

    Article  ADS  CAS  Google Scholar 

  21. Fujimoto, M., Kuninaka, A. & Yoshino, H. Agr. biol. Chem. 38, 1555–1561 (1974).

    Article  CAS  Google Scholar 

  22. Randerath, K. & Randerath, E. Analyt. Biochem. 13, 575–579 (1965).

    Article  CAS  Google Scholar 

  23. Miyamoto, C. & Denhardt, D. T. J. molec. Biol. 116, 681–707 (1977).

    Article  CAS  Google Scholar 

  24. Flory, J. P. thesis, Calif. Inst. Tech. (1976).

  25. Boezi, J. A. & Armstrong, R. L. Meth. Enzym. 12, A, 684–686 (1967).

    Article  Google Scholar 

  26. Bailey, J. M. & Davidson, N. Analyt. Biochem. 70, 75–85 (1977).

    Article  Google Scholar 

  27. Godson, G. N. & Roberts, R. J. Virology 73, 561–567 (1976).

    Article  CAS  Google Scholar 

  28. Attardi, G., Crews, S. T., Nishiguchi, J., Ojala, D. K. & Posakony, J. W. Cold Spring Harb. Symp. quant. Biol. 43 (in the press).

  29. Pribnow, D. Proc. natn. Acad. Sci. U.S.A. 72, 784–788 (1975).

    Article  ADS  CAS  Google Scholar 

  30. Tomizawa, J.-L., Ohmori, H. & Bird, R. E. Proc. natn. Acad. Sci. U.S.A. 74, 1865–1869 (1977).

    Article  ADS  CAS  Google Scholar 

  31. Langeveld, S. A. et al. Nature 271, 417–420 (1978).

    Article  ADS  CAS  Google Scholar 

  32. Geider, K., Beck, E. & Schaller, H. Proc. natn. Acad. Sci. U.S.A. 75, 645–649 (1978).

    Article  ADS  CAS  Google Scholar 

  33. Giddes, J. C., Barrell, B. G. & Godson, G. N. Proc. natn. Acad. Sci. U.S.A. 75, 1081–1085 (1978).

    Article  ADS  Google Scholar 

  34. Kallenbach, N. R. J. molec. Biol. 37, 445–466 (1968).

    Article  CAS  Google Scholar 

  35. Tinoco, I. Jr, et al. Nature new Biol. 246, 40–41 (1973).

    Article  CAS  Google Scholar 

  36. Borer, P. N., Dengler, B., Tinoco, L., Jr . & Uhlenbeck, D. C. J. molec. Biol. 86, 843–853 (1974).

    Article  CAS  Google Scholar 

  37. Gralla, J. & Crothers, D. M. J. molec. Biol 73, 497–511 (1973).

    Article  CAS  Google Scholar 

  38. Subramanian, K. N., Dhar, R. & Weissman, S. M. J. biol Chem. 252, 355–367 (1977).

    CAS  PubMed  Google Scholar 

  39. Tijan, R. Cell 13, 165–179 (1978).

    Article  Google Scholar 

  40. Dhar, R., Lai, C.-J. & Khoury, G. Cell 13, 345–358 (1978).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125

    Stephen Crews, Deanna Ojala, James Posakony, Jerry Nishiguchi & Giuseppe Attardi

Authors
  1. Stephen Crews
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Deanna Ojala
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James Posakony
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jerry Nishiguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giuseppe Attardi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crews, S., Ojala, D., Posakony, J. et al. Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication. Nature 277, 192–198 (1979). https://doi.org/10.1038/277192a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/277192a0

  • Springer Nature Limited

This article is cited by

Search

Navigation