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The influence of thymus on the development of MHC restrictions exhibited by T-helper cells

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Abstract

IMMUNE functions depend largely on the activities of peripheral lymphocytes which have been ‘processed’ in the thymus (T cells). The best characterised activities of these cells, such as in vitro cytotoxicity and suppressor and helper capacities in adoptive immunisations seem to be mediated by distinct subpopulations. However, it has emerged that T cells of all subpopulations exhibit a dual recognition faculty, on the one hand, towards entities coded by the major histocompatibility gene complex (MHC). and on the other towards foreign antigens. Without appropriate MHC recognition ‘foreignness’ may not be noticed, giving rise in various functional assays to what has been termed MHC restriction. For example, in the mouse, T cells may lack cytotoxicity unless they have H–2 region gene products1, in common with their target cells. T cells which ‘help’ in antibody responses can only do so fully if the B cells with which they are cooperating have similar I-region coding2. These various restrictions were thought to represent the need for interaction of like substances on cell surfaces perhaps to establish propinquity before any subsequent interactions could be initiated. Recently, however, it has been demonstrated3,4 that irradiated bone marrow chimaeras of the type A + B → (A × B)F1 possessed populations of T cells of A and B origin each of which was capable of interacting with B-cell populations of both A and B origin (A and B are used here purely as symbols for MHC-disparate mouse strains). Thus it seemed whatever the genetic determinacy of the cell, it could, when appropriately conditioned, establish reactions based on identity with either genetically similar or genetically different cells2,5. The exact nature of this conditioning began to emerge from experiments of Bevan6 and Zinkernagel7 who found that T cells from (A × B)F1A chimaeras could only kill target cells bearing A type MHC determinants, whilst no cytotoxicity towards B targets was possible. Comparable studies gave analogous results for helper T cells8,9 and recently, it was shown that the events which seem to determine the pattern of H–2 restricted specifities of the T cells concerned with cytotoxicity occur within the thymus gland7. We now show that intrathymic conditioning also determines the restriction specificities of T cells involved in helping antibody production.

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References

  1. Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974).

    Article  ADS  CAS  Google Scholar 

  2. Katz, D. H. & Benacerraf, B. in The Role of Products of the Histocompatibility Gene Complex in Immune Responses (eds Katz, D. H. & Benacerraf, B.). 355–400 (Academic, New York, 1976).

    Book  Google Scholar 

  3. von Boehmer, H., Hudson, L. & Sprent, J. J. exp. Med. 142, 989–997 (1975).

    Article  CAS  Google Scholar 

  4. Waldmann, H., Pope, H. & Munro, A. J. Nature 258, 728–730 (1975).

    Article  ADS  CAS  Google Scholar 

  5. Waldmann, H. Immun. Rev. 35, 121–145 (1977).

    Article  CAS  Google Scholar 

  6. Bevan, M. J. J. exp. Med. 142, 1349–1350 (1977).

    Article  Google Scholar 

  7. Zinkernagel, R. M. et al. J. exp. Med. 147, 897–908 (1978).

    Article  CAS  Google Scholar 

  8. Waldmann, H., Pope, H., Brent, L. & Bighouse, K. Nature 274, 166–167 (1978).

    Article  ADS  CAS  Google Scholar 

  9. Sprent, J. J. exp. Med. 147, 1838–1840 (1978).

    Article  CAS  Google Scholar 

  10. Dukor, P., Miller, J. F. A. P., House, W. & Allman, V. Transplantation 3, 639–668 (1965).

    Article  CAS  Google Scholar 

  11. Hays, E. F. & Alpert, P. F. J. exp. Med. 130, 847–857 (1969).

    Article  CAS  Google Scholar 

  12. Urso, P. & Gengozian, N. J. Immun. 113, 1170–1179 (1974).

    Google Scholar 

  13. Munro, A. J. & Waldmann, H. Br. med. Bull. 34, 253–258 (1978).

    Article  CAS  Google Scholar 

  14. Von Boehmer, H., Haas, W. & Jerne, N. K. Proc. natn. Acad. Sci. U.S.A. 75, 2439–2442.

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WALDMANN, H., POPE, H., BETTLES, C. et al. The influence of thymus on the development of MHC restrictions exhibited by T-helper cells. Nature 277, 137–138 (1979). https://doi.org/10.1038/277137a0

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