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Synthesis of growth hormone by bacteria

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Abstract

A hybrid gene was constructed between the β-lactamase gene of plasmid pBR322 and the cloned coding sequence for rat growth hormone. This gene is expressed in bacteria and growth hormone sequences are detectable by immunological methods.

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Authors and Affiliations

  1. Howard Hughes Medical Institute Laboratory, Department of Biochemistry and Biophysics, Department of Medicine, and Metabolic Research Unit, University of California, San Francisco, California, 94143

    P. H. Seeburg, J. Shine, J. A. Martial, R. D. Ivarie, J. A. Morris, A. Ullrich, J. D. Baxter & H. M. Goodman

Authors
  1. P. H. Seeburg
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  2. J. Shine
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  3. J. A. Martial
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  4. R. D. Ivarie
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  5. J. A. Morris
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  6. A. Ullrich
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  7. J. D. Baxter
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  8. H. M. Goodman
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Seeburg, P., Shine, J., Martial, J. et al. Synthesis of growth hormone by bacteria. Nature 276, 795–798 (1978). https://doi.org/10.1038/276795a0

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  • DOI: https://doi.org/10.1038/276795a0

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