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Alterations in β-adrenergic receptor binding during ethanol withdrawal

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Abstract

CHARACTERISTIC features of ethanol withdrawal, including tremor, agitation, seizures, tachycardia and increased blood pressure, frequently develop in chronic alcoholics 6–60 h after the discontinuation of long-term heavy ethanol consumption1–4. Similar symptoms are seen in hyperadrenergic states such as anxiety and thyrotoxicosis5,6. There is evidence to suggest that augmented sensitivity to catecholamines in thyrotoxicosis is due to the development of β-adrenergic receptor supersensitivity in cardiac and skeletal muscle cell surfaces7–10. Propranolol, a β-adrenergic blocker, has been shown to control some of the clinical signs of ethanol withdrawal, such as arrhythmia, hypertension and tremor11–13. In addition, propranolol significantly decreases urinary excretion of noradrenaline during ethanol withdrawal14. These findings have led to the suggestion that peripheral manifestations of increased adrenergic activity in ethanol withdrawal are secondary to increased sympathetic neural outflow and that this increase in central catecholaminergic outflow may be the result of increased β-adrenergic receptor sensitivity in the alcohol withdrawal state in man14. We report here attempts to determine whether increased central and peripheral β-adrenergic receptor binding could be demonstrated in rats during ethanol withdrawal.

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References

  1. Victor, M. Psychosom. Med. 28, 636–650 (1966).

    Article  Google Scholar 

  2. Victor, M. Postgrad. Med. 47, 68–72 (1970).

    Article  CAS  Google Scholar 

  3. Gross, M. M., Lewis, E. & Hastey, J. in Clinical Pathology Vol. 3 (eds Kissin, B. & Begleiter, H.) 191–263 (Plenum, New York, 1974).

    Google Scholar 

  4. Sellers, E. M. & Kalant, H. New Engl. J. Med. 294, 757–762 (1976).

    Article  Google Scholar 

  5. Marsden, C. D., Gimlette, T. M., McAllister, R. G., Owen, D. A. L. & Miller, T. N. Acta Endocrinol. 57, 353–362 (1968).

    Article  CAS  Google Scholar 

  6. Marsden, C. D., Meadows, J. C. & Lange, G. W. J. Neurol. Neurosurg. Psychiat., Lond. 33, 776–782 (1970).

    Article  CAS  Google Scholar 

  7. Banerjee, S. P. & Kung, L. S. Eur. J. Pharmac. 43, 207–208 (1977).

    Article  CAS  Google Scholar 

  8. Sharma, V. K. & Banerjee, S. P. Biochim. biophys. Acta 539, 538–542 (1978).

    Article  CAS  Google Scholar 

  9. Ciaraldi, T. & Marinetti, G. V. Biochem. biophys. Res. Commun. 74, 984–991 (1977).

    Article  CAS  Google Scholar 

  10. Williams, L. T., Lefkowitz, R. J., Watanabe, A. M., Hathaway, D. R. & Besch, H. R., Jr J. biol. Chem. 252, 2787–2789 (1977).

    CAS  PubMed  Google Scholar 

  11. Carlsson, C. & Johannson, T. Br. J. Psychiat. 119, 605–606 (1971).

    Article  CAS  Google Scholar 

  12. Zilm, D. H., Sellers, E. M., Macleod, S. M. & Degani, N. C. Ant. Int. Med. 83, 234–236 (1974).

    Article  Google Scholar 

  13. Sellers, E. M., Zilm, D. H., Degani, N. C. & MacLeod, S. M. Clin. Res. 23, 610A (1975).

    Google Scholar 

  14. Sellers, E. M., Degani, N. C., Zilm, D. H. & MacLeod, S. M. Lancet i, 94–95 (1976).

    Article  Google Scholar 

  15. Khanna, J. M., Kalant, H. & Bustos, G. Can. J. physiol. Pharmac. 45, 777–785 (1967).

    Article  CAS  Google Scholar 

  16. Bylund, D. R. & Snyder, S. H. Molec. Pharmac. 12, 568–580 (1976).

    CAS  Google Scholar 

  17. Banerjee, S. P., Kung, L. S., Riggi, S. J. & Chanda, S. K. Nature 268, 455–456 (1977).

    Article  ADS  CAS  Google Scholar 

  18. Sharma, V. K. & Banerjee, S. P. J. biol. Chem. 252, 7444–7446 (1977).

    CAS  Google Scholar 

  19. Banerjee, S. P., Sharma, V. K., Kung, L. S. & Chanda, S. K. Nature 271, 380–381 (1978).

    Article  ADS  CAS  Google Scholar 

  20. Israel, M. A., Kimura, H. & Kuriyama, K. Experientia 28, 1322–1323 (1972).

    Article  CAS  Google Scholar 

  21. French, S. W., Reid, P. E., Palmer, D. S., Narod, M. E. & Ramey, C. W. Res. Commun. chem. pathol. Pharmac. 6, 651–662 (1973).

    CAS  Google Scholar 

  22. French, S. W., Palmer, D. S., Narod, M. E., Reid, P. E. & Remey, C. W., J. Pharmac. exp. Ther. 194, 319–326 (1975).

    CAS  Google Scholar 

  23. Burt, D. R., Creese, I. & Snyder, S. H. Science 196, 326–327 (1977).

    Article  ADS  CAS  Google Scholar 

  24. Groves, P. M. & Rebec, G. V., Ann. Rev. Psychol. 27, 91–128 (1976).

    Article  CAS  Google Scholar 

  25. Sulser, F., Vetulani, J. & Mobley, P. L. Biochem. Pharmac. 27, 257–262 (1978).

    Article  CAS  Google Scholar 

  26. Iversen, L. L. In Handbook of Psychopharmacology, Vol III (eds Iversen, L. L., Iversen, S. D. & Snyder, S. H.) 381–442 (Plenum, New York).

  27. Sharma, V. K. & Banerjee, J. P. Eur. J. Pharmac. 41, 417–429 (1977).

    Article  CAS  Google Scholar 

  28. Knox, W. H., Perrin, R. G. & Sen, A. K. J. Neurochem. 19, 2881–2884 (1972).

    Article  CAS  Google Scholar 

  29. Sharma, V. K., Nagraj, M. G. & Banerjee, S. P. Brain Res. 129, 183–186 (1977).

    Article  CAS  Google Scholar 

  30. Banerjee, S. P. & Sharma, V. K. Br. J. Pharmac. 62, 475–579 (1978).

    Article  CAS  Google Scholar 

  31. Rangaraj, N. & Kalant, H. Biochem. Pharmac. (in the press).

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642

    SHAILESH P. BANERJEE & VIRENDRA K. SHARMA

  2. Department of Pharmacology, University of Toronto, and Addiction Research Foundation of Ontario, Toronto, Canada

    JATINDER M. KHANNA

Authors
  1. SHAILESH P. BANERJEE
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  2. VIRENDRA K. SHARMA
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  3. JATINDER M. KHANNA
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BANERJEE, S., SHARMA, V. & KHANNA, J. Alterations in β-adrenergic receptor binding during ethanol withdrawal. Nature 276, 407–409 (1978). https://doi.org/10.1038/276407a0

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