Abstract
IT is now established that a change in intracellular free Ca2+ forms a vital link in the action of certain hormones and neuro-transmitters as well as in excitation-secretion and excitation-contraction coupling1–5. Here we report an increase in intracellular free Ca2+ (Cai2+), brought about by exposure of muscle fibres to CO2. This effect may provide an important clue to the mode of action of CO2 in muscle cells as well as to a possible regulation of Cai2+ by changes in intracellular pH (pHi).
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LEA, T., ASHLEY, C. Increase in free Ca2+ in muscle after exposure to CO2. Nature 275, 236–238 (1978). https://doi.org/10.1038/275236a0
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DOI: https://doi.org/10.1038/275236a0
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