Skip to main content
Log in

Electrophoretic movement and localization of acetylcholine receptors in the embryonic muscle cell membrane

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

A steady electric field of 30 mV across a single embryonic muscle cell produces accumulation of acetylcholine receptors toward one pole of the cell within 1 h. The movement is electrophoretic in nature and the accumulation results in the formation of stable, metabolically independent receptor aggregates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Singer, S. J. & Nicolson, G. L. Science 175, 720–731 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Edidin, M. Ann. Rev. Biophys. 3, 179–201 (1974).

    Article  CAS  Google Scholar 

  3. Lee, A. G. Prog. Biophys. molec. Biol. 29, 3–56 (1975).

    Article  CAS  Google Scholar 

  4. Poo, M-m. & Cone, R. A. Nature 247, 438–441 (1974).

    Article  ADS  CAS  Google Scholar 

  5. Poo, M-m & Robinson, K. R. Nature 265, 602–605 (1977).

    Article  ADS  CAS  Google Scholar 

  6. Diamond, J. & Miledi, R. J. Physiol., Lond. 162, 393–408 (1962).

    Article  CAS  Google Scholar 

  7. Sytkowski, A. J., Vogel, Z. & Nirenberg, M. W. Proc. natn. Acad. Sci. U.S.A. 70, 270–274 (1973).

    Article  ADS  CAS  Google Scholar 

  8. Cohen, S. A. & Fischbach, G. D. Devl Biol. 59, 24–38 (1977).

    Article  CAS  Google Scholar 

  9. Kidokoro, Y., Heinemann, S., Schubert, D., Brandt, B. L. & Klier, F. G. Cold Spring Harb. Symp quant. Biol. 40, 373–388 (1976).

    Article  CAS  Google Scholar 

  10. Edidin, M. & Fambrough, D. J. Cell Biol. 57, 27–37 (1973).

    Article  CAS  Google Scholar 

  11. Poo, M-m, Poo, W-j. H. & Lam, J. J. Cell Biol. 76, 483–501 (1978).

    Article  CAS  Google Scholar 

  12. Anderson, M. J. & Cohen, M. W. J. Physiol., Lond. 268, 757–773 (1977).

    Article  CAS  Google Scholar 

  13. Fischbach, G. D., Berg, D. K., Cohen, S. A. & Frank, E. Cold Spring Harb. Symp. quant. Biol. 40, 347–357 (1976).

    Article  CAS  Google Scholar 

  14. Nieuwkoop, P. D. & Faber, J. Normal Table of Xenopus laevis (North-Holland, Amsterdam, 1962).

    Google Scholar 

  15. Jones, K. W. & Elsdale, T. R. J. Embryol. exp. Morph. 11, 135–154 (1963).

    CAS  PubMed  Google Scholar 

  16. Spitzer, N. C. J. Physiol., Lond. 255, 105–135 (1976).

    Article  CAS  Google Scholar 

  17. Miledi, R. J. Physiol. Lond., 151, 1–23 (1960).

    Article  CAS  Google Scholar 

  18. Kuffler, S. W. & Yoshikami, D. J. Physiol. Lond. 224, 703–730 (1975).

    Article  Google Scholar 

  19. Fischbach, G. D. & Cohen, S. A. Devl Biol. 31, 147–162 (1973).

    Article  CAS  Google Scholar 

  20. Nicolson, G. L. Int. Rev. Cytol. 39, 89–190 (1974).

    Article  CAS  Google Scholar 

  21. Nicolson, G. L. Biochem. biophys. Acta 457, 57–108 (1976).

    CAS  PubMed  Google Scholar 

  22. Brockes, J. P. & Hall, Z. W. Biochemistry 14, 2100–2106 (1975).

    Article  CAS  Google Scholar 

  23. Eylar, E. H., Madoff, M. A., Brody, O. V. & Oncley, J. L. J. biol. Chem. 237, 1992–2000 (1962).

    CAS  PubMed  Google Scholar 

  24. Poo, M-m. & Poo, W-j. H. Science (submitted).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Orida, N., Poo, Mm. Electrophoretic movement and localization of acetylcholine receptors in the embryonic muscle cell membrane. Nature 275, 31–35 (1978). https://doi.org/10.1038/275031a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/275031a0

  • Springer Nature Limited

This article is cited by

Navigation