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Internalisation of gonadotrophin–receptor complex in ovarian luteal cells

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Abstract

IT is generally accepted that peptide and protein hormones bind to plasma membrane receptors on target cells1 and elicit their acute responses without entering the cell. The refractory or desensitised state induced by various hormones in target tissues has been shown to be mediated at least in part by loss of specific receptor sites from the plasma membrane2–7. Evidence that certain protein hormones can enter target cells8–10 led us to the present investigation which provides evidence that gonadotrophin-induced receptor loss may occur by a process of internalisation of the hormone–receptor complex following the initial interaction of gonadotrophin with the cell surface.

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References

  1. Catt, K. J. & Dufau, M. L. Biol. Reprod. 14, 1–5 (1976).

    Article  CAS  Google Scholar 

  2. Gavin, J. R., Roth, J., Neville, D. M., De Meyts, P. & Buell, D. N. Proc. natn. Acad. Sci. U.S.A. 71, 84–88 (1974).

    Article  ADS  CAS  Google Scholar 

  3. Kebabian, J. W., Zatz, M., Romero, J. A. & Axelrod, J. Proc. natn. Acad. Sci. U.S.A. 72, 3735–3739 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Conti, M., Harwood, J. P., Hsueh, A. J. W., Dufau, M. L. & Catt, K. J. J. biol. Chem. 251, 7729–7731 (1976).

    CAS  PubMed  Google Scholar 

  5. Hsueh, A. J. W., Dufau, M. L. & Catt, K. J. Biochem. biophys. Res. Commun. 72, 1145–1151 (1976).

    Article  CAS  Google Scholar 

  6. Mukherjee, C., Caron, M. G. & Lefkowitz, R. J. Proc. natn. Acad. Sci. U.S.A. 72, 1945–1949 (1975).

    Article  ADS  CAS  Google Scholar 

  7. Hsueh, A. J. W., Dufau, M. L. & Catt, K. J. Proc. natn. Acad. Sci. U.S.A. 74, 592–595 (1977).

    Article  ADS  CAS  Google Scholar 

  8. Nordquist, R. E. & Palmieri, G. M. A. Endocrinology 95, 229–237 (1974).

    Article  CAS  Google Scholar 

  9. Nolin, J. M. & Witorsch, R. J. Endocrinology 99, 949–958 (1976).

    Article  CAS  Google Scholar 

  10. Carpenter, G. & Cohen, S. J. Cell Biol. 71, 159–171 (1976).

    Article  CAS  Google Scholar 

  11. Goldfine, I. D., Smith, G. J., Wong, K. Y. & Jones, A. L. Proc. natn. Acad. Sci. U.S.A. 74, 1368–1374 (1977).

    Article  ADS  CAS  Google Scholar 

  12. Lee, C. Y. & Ryan, R. Proc. natn. Acad. Sci. U.S.A. 69, 3520–3523 (1972).

    Article  ADS  CAS  Google Scholar 

  13. Conti, M., Harwood, J. P., Dufau, M. L. & Catt, K. J. Molec. Pharmac. 13, 1024–1032 (1977).

    CAS  Google Scholar 

  14. Kammerman, S., Canfield, R. E., Kolena, J. & Channing, C. P. Endocrinology 91, 65–74 (1972).

    Article  CAS  Google Scholar 

  15. Dufau, M. L., Charreau, E. H., Ryan, D. & Catt, K. J. FEBS Lett. 39, 149–153 (1974).

    Article  CAS  Google Scholar 

  16. Dufau, M. L., Podesta, E. J. & Catt, K. J. Proc. natn. Acad. Sci. U.S.A. 72, 1272–1275 (1975).

    Article  ADS  CAS  Google Scholar 

  17. Dufau, M. L., Charreau, E. H. & Catt, K. J. J. biol. Chem. 248, 6973–6982 (1973).

    CAS  PubMed  Google Scholar 

  18. Han, S. S., Rajaniemi, H. J., Cho, M. I., Hirschfield, A. N. & Midgley, A. R. Endocrinology 95, 589–598 (1974).

    Article  CAS  Google Scholar 

  19. Chen, T. T. et al. Cytobiologie 14, 412–420 (1977).

    CAS  PubMed  Google Scholar 

  20. Brown, M. S. & Goldstein, J. L. Science 191, 150–154 (1976).

    Article  ADS  CAS  Google Scholar 

  21. Unanue, E. R., Perkins, W. D. & Karnovsky, M. J. J. exp. Med. 136, 885–930 (1972).

    Article  CAS  Google Scholar 

  22. Castro, A. E., Alonso, A. & Mancini, R. E. J. Endocr. 52, 129–136 (1972).

    Article  CAS  Google Scholar 

  23. Posner, B. I., Kelly, P. A., Shiu, R. P. C. & Friesen, H. G. Endocrinology 95, 521–531 (1974).

    Article  CAS  Google Scholar 

  24. Goldfine, I. D. & Smith, G. J. Proc. natn. Acad. Sci. U.S.A. 73, 1427–1431 (1976).

    Article  ADS  CAS  Google Scholar 

  25. Ascoli, M. & Puett, D. FEBS Lett. 75, 77–82 (1977).

    Article  CAS  Google Scholar 

  26. Salpeter, M. M. & Bachmann, L. in Principles and Techniques of Electron Microscopy 2, (ed. Hayat, M.A.) (Van Nostrand, New York, 1972).

    Google Scholar 

  27. Laemmli, U. K. Nature 227, 680–685 (1970).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20014

    P. MICHAEL CONN, MARCO CONTI, JAMES P. HARWOOD, MARIA L. DUFAU & KEVIN J. CATT

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  1. P. MICHAEL CONN
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  2. MARCO CONTI
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  3. JAMES P. HARWOOD
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  4. MARIA L. DUFAU
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  5. KEVIN J. CATT
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CONN, P., CONTI, M., HARWOOD, J. et al. Internalisation of gonadotrophin–receptor complex in ovarian luteal cells. Nature 274, 598–600 (1978). https://doi.org/10.1038/274598a0

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