Skip to main content

Advertisement

SpringerLink
Log in

A common progenitor for human myeloid and lymphoid cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE pluripotent haemopoietic stem cell has been the object of many investigations in murine and human systems, but the origin of lymphoid cells from the human pluripotent stem cell has not been definitively established. In mice, investigations using the spleen colony technique1 have demonstrated the existence of a pluripotent stem cell which can give rise to mixed colonies of erythrocytes and granulocytes2. Further studies with radiation-induced chromosome markers in murine systems have provided evidence for the origin of lymphoid cells from this stem cell3–5. The use of X-linked glucose-6-phosphate dehydrogenase (G-6-PD) isoenzymes as cell markers has provided another approach, applicable to the evaluation of human proliferative disorders6,7. Those females with electrophoretically distinguishable G-6-PD isoenzymes who have clonal haematological disorders provide a source for such studies. Thus, Fialkow et al.8 have demonstrated the origin of erythrocytes, granulocytes, megakaryocytes, and macrophages from a myelogenous stem cell in studies of patients with chronic myelocytic leukaemia. We have used G-6-PD markers in a study of peripheral blood cells from a patient with acquired idiopathic sideroblastic anaemia, and shown the origin in humans of B and T lymphocytes from a common stem cell whose other progeny include erythrocytes, granulocytes, megakaryocytes, and macrophages. In addition, acquired idiopathic sideroblastic anaemia is shown, in this instance, to be a clonal disorder.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Till, J. E. & McCulloch, E. A. Radiat. Res. 14, 213–222 (1961).

    Article  CAS  ADS  Google Scholar 

  2. Wu, A. M., Till, J. E., Siminovitch, L. & McCulloch, E. A. J. cell. Physiol. 69, 177–184 (1967).

    Article  CAS  Google Scholar 

  3. Wu, A. M., Till, J. E., Siminovitch, L. & McCulloch, E. A. J. exp. Med. 127, 455–464 (1968).

    Article  CAS  Google Scholar 

  4. Trentin, J. et al. J. Immun. 98, 1326–1337 (1967).

    CAS  Google Scholar 

  5. Abramson, S., Miller, R. G. & Phillips, R. A. J. exp. Med. 145, 1567–1579 (1977).

    Article  CAS  Google Scholar 

  6. Linder, D. & Gartler, S. M. Science 150, 67–69 (1965).

    Article  CAS  ADS  Google Scholar 

  7. Fialkow, P. J. New. Engl. J. Med. 291, 26–35 (1974).

    Article  CAS  Google Scholar 

  8. Fialkow, P. J., Jacobson, R. J. & Papayannopoulou, T. Am. J. Med. 63, 125–130 (1977).

    Article  CAS  Google Scholar 

  9. Sparkes, R. S., Baluda, M. C. & Townsend, E. E. J. Lab. clin. Med. 73, 531–534 (1969).

    CAS  PubMed  Google Scholar 

  10. Beutler, E., West, C. & Blume, K.-G. J. Lab. clin. Med. 88, 329–333 (1976).

    Google Scholar 

  11. Bøyum, A. Scand. J. clin. Lab. Invest. 21, Suppl. 97, 1–109 (1968).

    Google Scholar 

  12. Moretta, L., Ferrarini, M., Durante, M. L. & Mingari, M. C. Eur. J. Immun. 5, 565–569 (1975).

    Article  CAS  Google Scholar 

  13. Adamson, J. W., Fialkow, P. J., Murphy, S., Prchal, J. F. & Steinmann, L. New. Engl. J. Med. 295, 913–916 (1976).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology and Oncology, University of Alabama in Birmingham, Birmingham, Alabama, 35294

    J. T. PRCHAL & D. W. THROCKMORTON

  2. Laboratory of Medical Genetics, University of Alabama in Birmingham, Birmingham, Alabama, 35294

    A. J. CARROLL III

  3. Department of Surgery, University of Alabama in Birmingham, Birmingham, Alabama, 35294

    E. W. FUSON

  4. Division of Hematology and Oncology, University of Alabama in Birmingham, Birmingham, Alabama, 35294

    R. A. GAMS

  5. Departments of Anatomy and Medicine, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada

    J. F. PRCHAL

Authors
  1. J. T. PRCHAL
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. W. THROCKMORTON
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. J. CARROLL III
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. W. FUSON
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. A. GAMS
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. F. PRCHAL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PRCHAL, J., THROCKMORTON, D., CARROLL, A. et al. A common progenitor for human myeloid and lymphoid cells. Nature 274, 590–591 (1978). https://doi.org/10.1038/274590a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/274590a0

  • Springer Nature Limited

This article is cited by

Search

Navigation