Abstract
INDUCTION of plaque-forming cells (PFC), specific for sheep red blood cells (SRBC) or ovalbumin (OA), from human peripheral blood requires the cooperation of surface IgM-positive B cells and E-rosette-forming T lymphocytes1,2. At high antigen concentrations PFC responses are suppressed2 and it seemed that this effect might be mediated in part by antigen-stimulated T lymphocytes2,3. We have studied the functional activity of purified T cells which had been preincubated (‘primed’) for 24 h in the presence of a high concentration of antigen. We report here that such primed cell preparations contain antigen-specific suppressor cells which interfere with the induction of PFC in autologous target PFC cultures. These suppressor cells and their precursors could be isolated in the theophylline-sensitive lymphocyte fraction4.
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References
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SHORE, A., DOSCH, HM. & GELFAND, E. Induction and separation of antigen-dependent T helper and T suppressor cells in man. Nature 274, 586–587 (1978). https://doi.org/10.1038/274586a0
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DOI: https://doi.org/10.1038/274586a0
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