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The covalent and tertiary structure of bovine liver rhodanese

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Abstract

Bovine liver rhodanese is a single polypeptide of 293 amino acids in which the halves of the molecule assume analogous tertiary structures in the absence of substantial sequence homology. The sulphur atom transferred during catalysis is bound in persulphide linkage to Cys-247. Substrate binding seems to involve Arg-186 and Lys-249.

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Authors and Affiliations

  1. Laboratorium voor Struktuurchemie, Rijksuniversiteit Groningen, Nijenborgh 16, 9747 AG, Groningen, The Netherlands

    Jan H. Ploegman, Gé Drent, Kor H. Kalk & Wim G. J. Hol

  2. Department of Biochemistry, The University 0f Chicago, 920 E. 58th Street, Chicago, Illinois, 60637

    Robert L. Heinrikson, Philip Keim, Litai Weng & John Russell

Authors
  1. Jan H. Ploegman
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  2. Gé Drent
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  3. Kor H. Kalk
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  4. Wim G. J. Hol
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  5. Robert L. Heinrikson
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  6. Philip Keim
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  7. Litai Weng
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  8. John Russell
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Ploegman, J., Drent, G., Kalk, K. et al. The covalent and tertiary structure of bovine liver rhodanese. Nature 273, 124–129 (1978). https://doi.org/10.1038/273124a0

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  • DOI: https://doi.org/10.1038/273124a0

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