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Effects in vitro of the proposed antisickling agent DBA

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Abstract

A VARIETY of antisickling substances, both synthetic and naturally occurring, have been studied for their potential value as agents for the treatment of sickle cell disease. 3,4-dihydro-2, 2-dimethyl-2H-l-benzopyran-6-butyric acid (DBA), a chemically modified derivative of xanthoxylol isolated from Fagara zanthoxyloides, has been reported to prevent as well as reverse sickling of sickle cell anaemia erythrocytes1. 10 mM DBA was described as being able virtually to abolish sickling within a period of 30 min1. We have examined the effect of DBA on washed erythrocytes prepared from blood of sickle cell anaemia patients, and report here that we have been unable to demonstrate any antisickling effect of DBA.

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References

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Authors and Affiliations

  1. Division of Hematology, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, Illinois, 60614

    GEORGE R. HONIG, LOYDA N. VIDA & CHRISTINE FERENC

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  1. GEORGE R. HONIG
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  2. LOYDA N. VIDA
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  3. CHRISTINE FERENC
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HONIG, G., VIDA, L. & FERENC, C. Effects in vitro of the proposed antisickling agent DBA. Nature 272, 833–834 (1978). https://doi.org/10.1038/272833a0

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  • DOI: https://doi.org/10.1038/272833a0

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