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Ovulation in rhesus monkeys suppressed by intranasal administration of progesterone and norethisterone

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Abstract

THE importance of various brain structures in the regulation of secretion of gonadotropins1–3 and the presence of steroid hormones in the cerebrospinal fluid (CSF)4–5 suggest that a method for delivering steroids into the CSF might be useful in the control of fertility. Steroids can enter the cerebral components rapidly after intranasal administration and their concentrations are higher than after intravenous injection6. We report here that progesterone and norethisterone given intranasally can prevent ovulation in rhesus monkeys.

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Authors and Affiliations

  1. Neuroendocrine Research Laboratory, Department of Anatomy, WHO Collaborating Centre for Research and Training in Human Reproduction, All India Institute of Medical Sciences, New Delhi, 110 016, India

    T. C. ANAND KUMAR, G. F. X. DAVID & V. PURI

Authors
  1. T. C. ANAND KUMAR
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  2. G. F. X. DAVID
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  3. V. PURI
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KUMAR, T., DAVID, G. & PURI, V. Ovulation in rhesus monkeys suppressed by intranasal administration of progesterone and norethisterone. Nature 270, 532–534 (1977). https://doi.org/10.1038/270532a0

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  • DOI: https://doi.org/10.1038/270532a0

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