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Nature of lethality of t mutations in embryos

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Abstract

Mutations in the genes of the T complex in mice can lead to death at various stages ofembryogenesis. It has been suggested that the T genes specify cell surface antigens which are essential for normal organisation of certain cells within the embryo. But, there is now evidence that at least some of these T complex mutations are simply generalised cell lethals.

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Authors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, 07110

    Linda R. Wudl & Michael I. Sherman

  2. Department of Biology, Temple University, Philadelphia, Pennsylvania, 19122

    Nina Hillman

Authors
  1. Linda R. Wudl
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  2. Michael I. Sherman
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  3. Nina Hillman
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Wudl, L., Sherman, M. & Hillman, N. Nature of lethality of t mutations in embryos. Nature 270, 137–140 (1977). https://doi.org/10.1038/270137a0

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