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Receptor that leaves a sour taste in the mouth

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Abstract

The ability to detect taste stimuli results from the activation of taste receptors located in taste-bud cells. There are several gustatory transduction mechanisms, involving membrane receptors, guanine-nucleotide-binding proteins (G proteins), second messengers and ion channels1, but genes encoding taste receptors have not yet been identified. Here we identify a complementary DNA that encodes a receptor for sour tastes.

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Figure 1: Expression and localization of MDEG1.
Figure 2: Expression of MDEG1 in Xenopus oocytes.

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Authors and Affiliations

  1. Department of Anatomy II, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Nagoya, 467–8601, Mizuho-ku, Japan

    Shinya Ugawa, Wei Guo, Yoshitsugu Saishin & Shoichi Shimada

  2. Department of Anatomy and Neuroscience, Osaka University Medical School, 2-2 Yamadaoka, Suita, 565–0871, Osaka, Japan

    Shinya Ugawa, Yuki Minami, Wei Guo, Yoshitsugu Saishin, Koichi Takatsuji & Masaya Tohyama

  3. Department of Behavioural Physiology, Faculty of Human Sciences, Osaka University, 1-2 Yamadaoka, Suita, 565-0871, Osaka, Japan

    Takashi Yamamoto

Authors
  1. Shinya Ugawa
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  2. Yuki Minami
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  3. Wei Guo
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  4. Yoshitsugu Saishin
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  5. Koichi Takatsuji
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  6. Takashi Yamamoto
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  7. Masaya Tohyama
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  8. Shoichi Shimada
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Ugawa, S., Minami, Y., Guo, W. et al. Receptor that leaves a sour taste in the mouth. Nature 395, 555–556 (1998). https://doi.org/10.1038/26882

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