Abstract
ALTHOUGH there are a number of reports on virus-inhibiting substances, knowledge of those of bacterial origin is rather limited1–6. Horsfall and co-workers7,8 reported that polysaccharides of Klebsiella pneumoniae suppressed multiplication of pneumonia virus of mouse in vivo and of mumps in ovo. Carver et al.9–11 described virus-inhibiting factor(s) which they isolated from different species of bacteria belonging to both Gram-positive and Gram-negative groups. We report here that a substance or substances extracted from Streptococcus faecalis inhibited proliferation of certain human pathogenic viruses in vitro and in vivo.
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References
Tamm, I. & Eggers, H. J. in Viral and Rickettsial Infections of Man 4th edn (eds Horsfall, F. L., Jr & Tamm, I.) 305–338 (Lippincott, Philadelphia, 1965).
Herrmann, E. C., Jr et al. Ann. N.Y. Acad. Sci. 130, 1–482 (1965).
Second Conference on Antiviral Substances (eds Herrmann, E. C., Jr & Stinebring, W. R.) Ann. N.Y. Acad. Sci. 173, 1–844 (1970).
Antivirals with Clinical Potential (ed. Merigan, T. C.) (University of Chicago Press, Chicago, 1976).
Becker, Y. Antiviral Drugs, Monographs in Virology, XI (ed. Melnick, J. L.) (Karger, Basel, 1976).
Third Conference on Antiviral Substances (ed. Herrmann, E. C., Jr) Ann. N.Y. Acad. Sci. 284, 1–720 (1977).
Horsfall, F. L., Jr & McCarty, M. J. exp. Med. 85, 623–646 (1947).
Ginsberg, H. S., Goebel, W. F. & Horsfall, F. L. Jr, J. exp. Med. 87, 385–410 (1948).
Carver, D. H. & Naficy, K., Proc. Soc. exp. Biol. Med. 111, 356–360 (1962).
Carver, D. H. & Naficy, K. Proc. Soc. exp. Biol Med. 116, 548–552 (1964).
Carver, D. H. & Rosen, F. S. Proc. Soc. exp. Biol. Med. 116, 575–579 (1964).
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. J. biol. Chem. 193, 265–275 (1951).
Dulbecco, R. & Vogt, M. J. exp. Med. 99, 167–182 (1954).
Younger, J. S., Keleti, G. & Feingold, D. S. Inf. Immun. 10, 1202–1206 (1974).
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HOTTA, S., KOJIMA, M., FUJISAKI, M. et al. An antiviral substance extracted from Streptococcus faecalis. Nature 268, 733–734 (1977). https://doi.org/10.1038/268733a0
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DOI: https://doi.org/10.1038/268733a0
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