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Sodium and calcium action potential in pituitary cells

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Abstract

SEVERAL endocrine cells or their neoplastic derivatives generate action potentials similar to those seen in neurones1, and in the adrenal chromaffin cell such regenerative potentials depend primarily on a sodium mechanism2–4. Kidokoro has described action potentials in the GH3 rat pituitary cell line which seem to depend on a calcium mechanism5. We have re-investigated the action potential in GH3 cells and found that it results from combined Na and Ca mechanisms in physiological conditions. In addition, we have recorded similar electrical excitability from two human pituitary tumours grown in vitro.

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Authors and Affiliations

  1. Departments of Neurology and Pathology, Beth Israel Hospital/Harvard Medical School, Boston, Massachusetts, 02215

    BERNARD BIALES, MARC A. DICHTER & ARTHUR TISCHLER

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  1. BERNARD BIALES
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  2. MARC A. DICHTER
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  3. ARTHUR TISCHLER
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BIALES, B., DICHTER, M. & TISCHLER, A. Sodium and calcium action potential in pituitary cells. Nature 267, 172–174 (1977). https://doi.org/10.1038/267172a0

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  • DOI: https://doi.org/10.1038/267172a0

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