Abstract
DURING studies on the role of gonadal hormones in aggressive behaviour of mice, we observed large variations in both the morphology and behaviour of females. At birth, variation was evident with respect to the principal external sex-differentiating marker—distance between the anus and the genitals, with some females being difficult to distinguish from males. Moreover, a significant proportion of females, upon reaching adulthood, were more responsive to androgen than others, exhibiting male-like aggressive behaviour more quickly following its administration. These observations led to the speculation that a certain proportion of females had been masculinised naturally during prenatal development. We present here data which show that such masculinisation does occur and that it is mediated by proximity to male foetuses.
Similar content being viewed by others
References
Clemens, L. G. in Reproductive Behavior (eds Montagna, W. & Sadler, W. A.) (Plenum, New York, 1974).
Denenberg, V., Gaulin-Kremer, E., Gandelman, R. & Zarrow, M. X. Anim. Behav. 21, 590–598 (1973).
vom Saal, F. S., Svare, B. & Gandelman, R. Behavl Biol. 17, 391–397 (1976).
Winer, B. J. Statistical Principles in Experimental Design (McGraw-Hill, New York, 1962).
Bruce, N. W. & Norman, N. Nature 257, 62–63 (1975).
DeMoor, P., Verhoeven, G. & Heyns, W. Differentiation 1, 241–256 (1973).
Fels, E. & Bosch, L. R. Am. J. Obstet. Gynec. 111, 964–967 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GANDELMAN, R., VOM SAAL, F. & REINISCH, J. Contiguity to male foetuses affects morphology and behaviour of female mice. Nature 266, 722–724 (1977). https://doi.org/10.1038/266722a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/266722a0
- Springer Nature Limited
This article is cited by
-
Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance
Nature Communications (2024)
-
The phenotypic correlates and quantitative genetics of masculinization in the rodent, Octodon degus
Heredity (2017)
-
Nature, Niche, and Nurture
Academic Psychiatry (1998)
-
And brother begat nephew
Nature (1993)
-
Hormonally mediated inheritance of acquired characteristics in Mongolian gerbils
Nature (1993)