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Octopamine

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Abstract

The sympathomimetic amine octopamine (p-hydroxyphenylethanolamine) has the properties of a neurotransmitter in many invertebrate species. In mammals it seems to be a cotransmitter with noradrenaline.

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References

  1. Erspamer, V., and Boretti, G., Archs Int. Pharmacodyn. Ther., 88, 296–332 (1951).

    CAS  Google Scholar 

  2. Armstrong, M. D., Shaw, K. N. F., and Wall, P. E., J. biol. Chem., 218, 293–303 (1956).

    CAS  PubMed  Google Scholar 

  3. Kakimoto, Y., and Armstrong, M. D., J. biol. Chem., 237, 422–427 (1962).

    CAS  PubMed  Google Scholar 

  4. Fischer, J., Musacchio, J., Kopin, I. J., and Axelrod, J., Life Sci., 3, 413–419 (1964).

    Article  CAS  Google Scholar 

  5. Kopin, I. J., Fischer, J. E., Musacchio, J. M., Horst, W. D., and Weise, V. K., J. Pharmacol. Exp. Ther., 147, 186–193 (1965).

    CAS  PubMed  Google Scholar 

  6. Friedman, S., and Kaufman, S., J. biol. Chem., 240, 552–554 (1965).

    Google Scholar 

  7. Potter, L. T., and Axelrod, J., J. Pharmac. exp. Ther., 142, 291–298 (1963).

    CAS  Google Scholar 

  8. Pisano, J. J., Creveling, C. R., and Udenfriend, S., Biochim. biophys. Acta, 43 566–568 (1960).

    Article  CAS  Google Scholar 

  9. Molinoff, P. B., Landsberg, L., and Axelrod, J., J. Pharmac. exp. Ther., 179, 253–261 (1969).

    Google Scholar 

  10. Axelrod, J., J. biol. Chem., 237, 1657–1660 (1962).

    CAS  Google Scholar 

  11. Harmar, A. J., and Horn, A. S., J. Neurochem, 26, 987–993 (1976).

    Article  CAS  Google Scholar 

  12. Saavedra, J. M., Analyt. Biochem., 59, 628–633 (1974).

    Article  CAS  Google Scholar 

  13. Saavedra, J. M., Brownstein, M., and Axelrod, J., J. Pharmac. exp. Ther., 186 508–515 (1973).

    CAS  Google Scholar 

  14. Coyle, J. T., and Henry, D., J. Neurochem., 21, 61–67 (1973).

    Article  CAS  Google Scholar 

  15. Snyder, S. H., Baldessarini, R. J., and Axelrod, J., J. Pharmac. exp. Ther., 153 544–549 (1966).

    CAS  Google Scholar 

  16. Saavedra, J. M., and Axelrod, J., J. Pharmac. exp. Ther., 182, 363–369 (1972).

    CAS  Google Scholar 

  17. Saavedra, J. M., J. Neurochem., 33, 211–216 (1974).

    Article  Google Scholar 

  18. Tallman, J. F., Saavedra, J. M., Axelrod, J., J. Neurochem., 27, 465–469 (1976).

    Article  CAS  Google Scholar 

  19. Molinoff, P. B., and Axelrod, J., Science, 164, 428–429 (1969).

    Article  ADS  CAS  Google Scholar 

  20. Molinoff, P. B., and Axelrod, J., J. Neurochem., 19, 157–163 (1972).

    Article  CAS  Google Scholar 

  21. Saavedra, J. M., Coyle, J. T., and Axelrod, J., J. Neurochem., 23, 511–515 (1974).

    Article  CAS  Google Scholar 

  22. Molinoff, P. B., and Buch, S. H. in Trace Amines in the Brain (edit. by Sandler M., and Usdin, E.), 131–160 (Raven, New York, 1976).

    Google Scholar 

  23. Armstrong, M. D., McMillan, A., Shaw, K. N. F., Biochim. biophys. Acta, 25 422–423 (1957).

    Article  CAS  Google Scholar 

  24. Brandau, K., and Axelrod, J., Naunyn-Schmiedeberg's Arch. Pharmak., 273 123–133 (1972).

    Article  CAS  Google Scholar 

  25. Carlsson, A., and Waldeck, B., Acta pharmac. toxic. 20, 371–374 (1963).

    Article  CAS  Google Scholar 

  26. Axelrod, J., Inscoe, J. K., and Daly, J., J. Pharmac. exp. Ther., 149, 16–22 (1965).

    CAS  Google Scholar 

  27. Brandau, K., and Axelrod, J., in Frontiers in Catecholamine Research (edit. by Usdin, E., and Snyder, S. H.), 129–131 (Pergamon, New York, 1973).

    Book  Google Scholar 

  28. Jaim-Etchieverry, G., and Zieher, L. M., J. Neurochem., 25, 915–917 (1975).

    Article  Google Scholar 

  29. Baldessarini, R. J., and Vogt, M., J. Neurochem., 19, 755–761 (1972).

    Article  CAS  Google Scholar 

  30. Baldessarini, R. J., J. Neurochem., 18, 2509–2518 (1971).

    Article  CAS  Google Scholar 

  31. Lands, A. M., and Grant, J. E., J. Pharmac. exp. Ther., 106, 341–345 (1952).

    CAS  Google Scholar 

  32. Fischer, J. E., and Baldessarini, R. J., Lancet, ii, 75–80 (1971).

    Article  Google Scholar 

  33. Floyd, K. F., Davidson, L., Gall, D. G., and McCling, H. J., Proc. Fifth Annual Meeting for Society for Neurosciences, 394 (Society of Neuroscience, Bethesda, Md, 1975).

  34. Juorio, A. V., and Molinoff, P. B., J. Neurochem., 22, 271–280 (1974).

    Article  CAS  Google Scholar 

  35. Saavedra, J. M., Brownstein, M. J., Carpenter, D. O., and Axelrod, J., Science, 185, 364–365 (1974).

    Article  ADS  CAS  Google Scholar 

  36. Brownstein, M. J., Saavedra, J. M., Axelrod, J., Zeman, G. H., and Carpenter, D. O., Proc. natn. Acad. Sci. U.S.A., 71, 4662–4665 (1974).

    Article  ADS  CAS  Google Scholar 

  37. Barker, D. L., Molinoff, P. B., and Kravitz, E. A., Nature new Biol., 236, 61–63 (1972).

    Article  CAS  Google Scholar 

  38. Wallace, B. G., Talamo, B. R., Evans, P. D., and Kravitz, E. A., Brain Res., 74, 349–355 (1974).

    Article  CAS  Google Scholar 

  39. Evans, P. D., Talamo, B. R., and Kravitz, E. A., Brain Res., 90, 340–347 (1975).

    Article  CAS  Google Scholar 

  40. Robertson, H. A., and Steele, J. E., J. Physiol., Lond., 237, 34P–35P (1974).

    CAS  PubMed  Google Scholar 

  41. Hoyle, G., and Barker, D. L., J. exp. Zool., 193, 433–439 (1975).

    Article  CAS  Google Scholar 

  42. Robertson, H. A., Experientia, 31, 1006–1008 (1975).

    Article  CAS  Google Scholar 

  43. Robertson, H. A., and Carlsson, A. D., J. exp. Zool., 195, 159–164 (1976).

    Article  CAS  Google Scholar 

  44. Nathanson, J. A., and Greengard, P., Science, 180, 308–310 (1973).

    Article  ADS  CAS  Google Scholar 

  45. Robertson, H. A., and Steele, J. E., J. Neurochem., 19, 1603–1606 (1972).

    Article  CAS  Google Scholar 

  46. Carlsson, A. D., J. exp. Biol., 49, 195–199 (1968).

    Google Scholar 

  47. Hoyle, G., J. exp. Zool., 193, 425–431 (1975).

    Article  CAS  Google Scholar 

  48. Sullivan, R. E., and Barker, D. L., Proc. Fifth Annual meeting of the Society of Neurosciences, 394 (Society of Neuroscience, Bethesda, Md, 1975).

  49. Carpenter, D. O., and Gaubatz, G. L., Nature, 252, 483–485 (1974).

    Article  ADS  CAS  Google Scholar 

  50. Levitan, I. B., and Barondes, S. H., Proc. natn. Acad. Sci. U.S.A., 71, 1145–1148 (1974).

    Article  ADS  CAS  Google Scholar 

  51. Levitan, I. B., Madsen, C. J., and Barondes, S. H., J. Neurobiol., 5, 511–525 (1974).

    Article  CAS  Google Scholar 

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Axelrod, J., Saavedra, J. Octopamine. Nature 265, 501–504 (1977). https://doi.org/10.1038/265501a0

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  • DOI: https://doi.org/10.1038/265501a0

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