Abstract
DISCOVERED in 1931 by von Euler and Gaddum1 and purified to homogeneity in 1970 by Chang and Leeman2, stance P is an undecapeptide with the sequence H-Arg-Pro-lys-pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (ref. 3). Its function is still unknown but the selective distribution of substance P in the nervous system4–6, its localisation in nerve endings (refs 7–9 and our own unpublished results) and its neuropharmacological actions10–14 strongly suggest that substance P may participate, directly or indirectly, in the transmission process of certain neurones. However, if substance P is a neurotransmitter, it must also be released from nerve terminals upon the appropriate stimulation. In this report we present evidence showing that substance P is released from isolated nerve endings by depolarisation with high K+ and that this release is calcium dependent.
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Change history
01 February 1977
In 'Release of substance P from isolated nerve endings' by Christina Schenker, Edmund A. Mroz and Susan E. Leeman (Nature, 264, 791, 1976), line 9 should read . . . not be released by high K+ in the presence of Ca2+ . . .
References
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SCHENKER, C., MROZ, E. & LEEMAN, S. Release of substance P from isolated nerve endings. Nature 264, 790–792 (1976). https://doi.org/10.1038/264790a0
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DOI: https://doi.org/10.1038/264790a0
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