Abstract
BRAIN areas with the highest concentration of noradrenergic nerve terminals and noradrenaline (NA) have a circadian rhythm in their content of NA in the rabbit, rat and cat. The anterior and lateral hypothalamus1 and cervical spinal cord2, midbrain3 and caudate nucleus4, medial lower brain stem5 and frontal cortex6 all have significant circadian variations in their NA content. These brain regions have their highest NA level during the night in the rat, a nocturnal animal, and during the day in the rabbit and cat.
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WOOD, J., ZIEGLER, M., LAKE, C. et al. Circadian rhythm in cerebrospinal fluid noradrenaline of man and monkey. Nature 264, 656–658 (1976). https://doi.org/10.1038/264656a0
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DOI: https://doi.org/10.1038/264656a0
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