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Selective inhibition of neuronal GABA uptake by cis-1,3-aminocyclohexane carboxylic acid

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Abstract

IT is now generally accepted that GABA is an important inhibitory synaptic transmitter in the vertebrate central nervous system. However, there remain many problems in elucidating the precise roles of GABA in the brain. One important problem is the existence of a glial pool of GABA which makes it difficult to determine the origin of GABA released during experiments designed to demonstrate the release of GABA after nervous stimulation. It was thought at one time that this problem might be overcome by utilising the uptake processes for GABA to label the neuronal GABA pools, with for example, 3H-GABA. However, it is now clear that in many areas of the brain, GABA is also taken up by glial cells and in some areas, this glial uptake may actually predominate. The transport processes for GABA in neurones and glia have remarkably similar properties but do appear to have slightly different structural requirements.

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Authors and Affiliations

  1. Department of Pharmacology, St Thomas's Hospital Medical School, London, SE1 7EH, UK

    N. G. BOWERY

  2. William Ramsay, Ralph Forster and Christopher Ingold Laboratories, University College, London, WC1, UK

    G. P. JONES

  3. Department of Pharmacology, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, WC1N 1AX, UK

    M. J. NEAL

Authors
  1. N. G. BOWERY
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  2. G. P. JONES
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  3. M. J. NEAL
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BOWERY, N., JONES, G. & NEAL, M. Selective inhibition of neuronal GABA uptake by cis-1,3-aminocyclohexane carboxylic acid. Nature 264, 281–284 (1976). https://doi.org/10.1038/264281a0

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  • DOI: https://doi.org/10.1038/264281a0

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