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Experimental production of sheep pulmonary adenomatosis (Jaagsiekte)

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Abstract

SHEEP pulmonary adenomatosis (SPA) or Jaagsiekte is a contagious disease of unknown aetiology1. A herpesvirus has been isolated from such tumours in Britain2 and in Africa3,4 but attempts to produce adenomata with this virus have been unsuccessful (ref. 5 and W.B.M., G. Robinson, and K.W.A., in preparation). More recently, evidence has been presented that a type C virus with a density on a sucrose gradient of 1.5–1.20 g ml−1, containing 60–70S RNA and RNA-directed DNA polymerase (reverse transcriptase) is present in the adenomatous tissue6. We wish to describe the production of SPA tumours in sheep experimentally infected with both agents.

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Authors and Affiliations

  1. Animal Diseases Research Association, Moredun Institute, Edinburgh, EH17 7JH, UK

    WILLIAM B. MARTIN, FRANK M. M. SCOTT, JAMES M. SHARP & KENNETH W. ANGUS

  2. Virus Research Laboratory, Department of Bacteriology, Edinburgh University Medical School, Edinburgh, UK

    MARY NORVAL

Authors
  1. WILLIAM B. MARTIN
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  2. FRANK M. M. SCOTT
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  3. JAMES M. SHARP
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  4. KENNETH W. ANGUS
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  5. MARY NORVAL
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MARTIN, W., SCOTT, F., SHARP, J. et al. Experimental production of sheep pulmonary adenomatosis (Jaagsiekte). Nature 264, 183–185 (1976). https://doi.org/10.1038/264183a0

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  • DOI: https://doi.org/10.1038/264183a0

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