Skip to main content

Advertisement

SpringerLink
Log in

Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

SOMATOMEDINS are growth hormone-dependent polypeptides that have been proposed as the mediators of the peripheral actions of growth hormone on skeletal tissue1. Several polypeptides with somatomedin activity in vitro, including somatomedins A, B and C and non-suppressible insulin-like activity soluble in acid ethanol (NSILA-s)2–4, have been isolated from human plasma. Unique among polypeptide hormones, the somatomedins circulate in human blood complexed to binding proteins of larger molecular weight2,4–7. We report here the specific binding of a somatomedin-like polypeptide to distinct protein fractions in rat serum and further demonstrate that the pattern and level of this binding is dependent on growth hormone. We postulate that specific binding of somatomedin modulates the peripheral effects of somatomedin activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Daughaday, W. H., et al., Nature, 236, 107 (1972).

    Article  ADS  Google Scholar 

  2. Van Wyk, J., et al. Recent Prog. Hormone Res., 30, 259–318 (1974).

    CAS  Google Scholar 

  3. Froesch, E. R., et al., Adv. metabolic Dis., 8, 203–209 (1975).

    Article  CAS  Google Scholar 

  4. Hall, K., Takano, K., Enberg, G., and Fryklund, L., Proc. int. Symp. Growth Hormone, Milan, 1975 (Elsevier-Excerpta Medica, Amsterdam, in the press).

  5. Zapf, J., Waldyogel, M., and Froesch, E. R., Archs. Biochem. Biophys., 168, 638–645 (1975).

    Article  CAS  Google Scholar 

  6. Hintz, R. L., Orsini, E. M., and Van Camp, M. G., The Endocrine Society 56th Annual Meeting Program, A-71 (1974).

    Google Scholar 

  7. Yalow, R. S., Hall, K., and Luft, R., Adv. metabolic Dis., 8, 73–83, (1975).

    Article  CAS  Google Scholar 

  8. Cohen, K. L., and Nissley, S. P., Acta Endocr. (in the press).

  9. Dulak, N., and Temin, H., J. Cell Physiol., 81, 153–160 (1973).

    Article  CAS  Google Scholar 

  10. Nissley, S. P., Passamani, J., and Short, P., J. cell. Physiol. (in the press).

  11. Megyesi, K., et al., J. biol. Chem., 250, 8990–8996 (1975).

    CAS  PubMed  Google Scholar 

  12. Rechler, M. M., et al., The Endocrine Society 58th Annual Meeting Program 222 (1976).

    Google Scholar 

  13. Rechler, M. M., Podskalny, J. M., and Nissley, S. P., Nature, 159, 134–136 (1976).

    Article  ADS  Google Scholar 

  14. Smith, G. L., and Temin, H. M., J. cell Physiol., 84, 181–192 (1974).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. KENNETH L. COHEN

    Present address: Department of Medicine, Yale University, New Haven, Connecticut, 06520

Authors and Affiliations

  1. Endocrinology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    ALAN C. MOSES, S. PETER NISSLEY & KENNETH L. COHEN

  2. Diabetes Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    MATTHEW M. RECHLER

Authors
  1. ALAN C. MOSES
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. PETER NISSLEY
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. KENNETH L. COHEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. MATTHEW M. RECHLER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MOSES, A., PETER NISSLEY, S., COHEN, K. et al. Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone. Nature 263, 137–140 (1976). https://doi.org/10.1038/263137a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/263137a0

  • Springer Nature Limited

This article is cited by

Search

Navigation