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Rolling hairpin model for replication of parvovirus and linear chromosomal DNA

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Abstract

A novel, quasicircular scheme is proposed for the replication of parvovirus DNA. Daughter strands are initiated after the copying and rearrangement of a terminal palindromic sequence, a process termed ‘hairpin transfer’. Such a process may be involved in the replication of other viruses and host cell DNA.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Mill Hill Laboratories, Burtonhole Lane, London, NW7 1AD, UK

    Peter Tattersall

  2. Departments of Human Genetics and Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, 06510

    David C. Ward

Authors
  1. Peter Tattersall
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  2. David C. Ward
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Tattersall, P., Ward, D. Rolling hairpin model for replication of parvovirus and linear chromosomal DNA. Nature 263, 106–109 (1976). https://doi.org/10.1038/263106a0

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  • DOI: https://doi.org/10.1038/263106a0

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