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Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung

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Abstract

THE ability of lung tissue from various species to synthesise and release parent prostaglandins (PGs) has been well established1,2 and metabolic conversions of PGs occur rapidly after very efficient uptake from the circulation3,4. Using an isolated perfusion system to allow uptake of the PG precursor, arachidonic acid (1-14C labelled), the sensitised guinea pig lungs released a number of radiolabelled substances following challenge with specific antigen5. Our attempts to characterise these substances and prepare sufficient material for biological testing have revealed at least two compounds which have not been previously described and others not previously seen in this release system.

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Authors and Affiliations

  1. Pharmacological Research, Lilly Research Centre Limited, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK

    W. DAWSON & J. R. BOOT

  2. Physical Organic Research, Lilly Research Centre Limited, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK

    A. F. COCKERILL, D. N. B. MALLEN & D. J. OSBORNE

Authors
  1. W. DAWSON
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  2. J. R. BOOT
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  3. A. F. COCKERILL
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  4. D. N. B. MALLEN
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  5. D. J. OSBORNE
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DAWSON, W., BOOT, J., COCKERILL, A. et al. Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung. Nature 262, 699–702 (1976). https://doi.org/10.1038/262699a0

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  • DOI: https://doi.org/10.1038/262699a0

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