Abstract
WE have shown previously that a glycoprotein constituent of calcified cortical bone matrix is immunochemically identical to a component of blood plasma1,2. In bone and dentine this specific α-glycoprotein is concentrated in amounts relative to plasma albumin but is not present at greater concentrations than in plasma in various other tissues. This material, although mainly present in extra-vascular sites in bone, could originate from the plasma because it represents a substantial proportion of the radioactivity in bone tissue 12 d after injection of 14C-total plasma glycoprotein1. Rabbit bone α-glycoprotein is analogous to human α2HS-glycoprotein3,4, which is located in mineralising areas in normal human bone matrix5. To our knowledge direct conclusive proof of the tissue origin of the plasma α2HS-glycoprotein is lacking although most of the serum glycoproteins seem to be synthesised by the liver6,7. Nevertheless, its increased concentration in calcified tissues suggests that its presence in plasma could be a result of synthesis and release by bone tissue. We now report that the α2HS-glycoprotein is synthesised by the liver and a proportion is subsequently accumulated in bone tissue.
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TRIFFITT, J., GEBAUER, U., ASHTON, B. et al. Origin of plasma α2HS-glycoprotein and its accumulation in bone. Nature 262, 226–227 (1976). https://doi.org/10.1038/262226a0
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DOI: https://doi.org/10.1038/262226a0
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