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Muscarinic agonists provide a new class of acaricide

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Abstract

THE resistance of ticks to chemical methods of control is an increasingly serious problem1–5, and new classes of compounds with high acaricidal activity and low mammalian toxicity are needed urgently. In the search for novel acaricides the nervous system is a prime target, and, in spite of evidence about the role of γ-aminobutyrate and gluta-mate in arthropod nervous transmission, acetylcholine is the only well established neurotransmitter6–9. So far only acetylcholinesterases have achieved an important role in the disruption of cholinergic neurotransmission. Anti-cholinergics, such as atropine, are ineffective, and cholino-mimetics other than nicotine have been little investigated. We now report that certain muscarinic agonists are potent acaricides.

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References

  1. Whitehead, G. B., Adv. Acarol. 2, 53–70 (1965).

    CAS  Google Scholar 

  2. Roulston, W. J., and Wharton, R. H., Aust. Vet. J., 43, 129–134 (1967).

    Article  CAS  Google Scholar 

  3. Shaw, R. D., Cook, M., and Carson, R. E., J. econ. Ent., 61, 1590–1594 (1968).

    Article  CAS  Google Scholar 

  4. Wharton, R. H., and Roulston, W. J., A. Rev. Ent., 15, 381–404 (1970).

    Article  CAS  Google Scholar 

  5. Harrison, I. R., Palmer, B. H., and Wilmhurst, E. C., Pesticide Sci., 4, 531–542 (1973).

    Article  CAS  Google Scholar 

  6. O'Connor, A. K., O'Brien, R. D., and Salpeter, M. M., J. Insect. Physiol., 11, 1351–1358 (1965).

    Article  CAS  Google Scholar 

  7. Faeder, I. R., O'Brien, R. D., and Salpeter, M. M., J. exp. Zool., 173, 187–202 (1970).

    Article  CAS  Google Scholar 

  8. Pitman, R. M., Comp. gen. Pharmac., 2, 347–371 (1971).

    Article  CAS  Google Scholar 

  9. Gerschenfeld, H. M., Physiol. Rev., 53, 1–119 (1973).

    Article  CAS  Google Scholar 

  10. Hanin, I., Jenden, D. J., and Cho, A. K., Molec. Pharmac., 2, 352–359 (1966).

    CAS  Google Scholar 

  11. Bebbington, A., Brimblecombe, R. W., and Shakeshaft, D., Br. J. Pharmac., 26, 56–67 (1966).

    CAS  Google Scholar 

  12. Levy, J., and Michel-Ber, E., C. r. Séanc. hebd. Acad. Sci, Paris, 262, 2546–2549 (1966).

    CAS  Google Scholar 

  13. Levy, J., and Michel-Ber, E., Therapie, 22, 671–688 (1967).

    CAS  PubMed  Google Scholar 

  14. Karlen, B., Acta. pharm. suecica, 7, 169–200 (1970).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Pharmaceuticals Division, Imperial Chemical Industries Limited, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK

    D. C. H. BIGG & S. R. PURVIS

Authors
  1. D. C. H. BIGG
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  2. S. R. PURVIS
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BIGG, D., PURVIS, S. Muscarinic agonists provide a new class of acaricide. Nature 262, 220–222 (1976). https://doi.org/10.1038/262220a0

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